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10.18632/oncotarget.24613 http://scihub22266oqcxt.onion/10.18632/oncotarget.24613 C5880596!5880596!29632636     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (20): 15198-207 Nephropedia Template TP {{tp|p=29632636|t=2018. miR-145 expression enhances integrin expression in SK-GT-4 cell line by down-regulating c-Myc expression |pdf=|usr=}}{{29632636}} gab.com Text miR-145 expression enhances integrin expression in SK-GT-4 cell line by down-regulating c-Myc expression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29632636 #FOAvip Adenocarcinoma of the esophagus is increasing in frequency and is the 6th most common cause of cancer death in North America. In adenocarcinoma cell lines, we have previously demonstrated that expression of miR-145, leads to enhanced invasion, resistance to anoikis and better attachment to fibronectin in esophageal adenocarcinoma. In contrast, expression of miR-145 acts as a tumor suppressor in squamous cell carcinoma. The molecular mechanisms responsible for the oncogenic effects of miR-145 were investigated. In this report, we demonstrate that we can partially recreate the miR-145 effects in EAC by knock down of the expression of c-Myc, which is one of the targets of miR-145. Knocking down of c-Myc expression resulted in upregulation of integrin subunits ?5 and ?3. Finally, we demonstrated that integrin ?5 expression correlates to fibronectin attachment potential whereas integrin ?3 expression correlates with resistance to anoikis and invasion potential. Finally, we demonstrate that expression of miR-145 in esophageal adenocarcinoma cell line (SK-GT-4) enhances tumor growth and metastasis in a NOD/SCID xenograft model. Overall, the oncogenic potential of miR-145 in EAC appears to be mediated by downregulation of c-Myc leading to the expression of integrins subunits ?5 and ?3. Twit Text FOAVip miR-145 expression enhances integrin expression in SK-GT-4 cell line by down-regulating c-Myc expression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29632636 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632636 #FOAvip English Wikipedia <ref>{{Cite pmid|29632636}}</ref> miR-145 expression enhances integrin expression in SK-GT-4 cell line by down-regulating c-Myc expression #MMPMID29632636 Derouet MF; Dakpo E; Wu L; Zehong G; Conner J; Keshavjee S; de Perrot M; Waddell T; Elimova E; Yeung J; Darling GE Oncotarget 2018[Mar]; 9 (20): 15198-207 PMID29632636show ga Adenocarcinoma of the esophagus is increasing in frequency and is the 6th most common cause of cancer death in North America. In adenocarcinoma cell lines, we have previously demonstrated that expression of miR-145, leads to enhanced invasion, resistance to anoikis and better attachment to fibronectin in esophageal adenocarcinoma. In contrast, expression of miR-145 acts as a tumor suppressor in squamous cell carcinoma. The molecular mechanisms responsible for the oncogenic effects of miR-145 were investigated. In this report, we demonstrate that we can partially recreate the miR-145 effects in EAC by knock down of the expression of c-Myc, which is one of the targets of miR-145. Knocking down of c-Myc expression resulted in upregulation of integrin subunits ?5 and ?3. Finally, we demonstrated that integrin ?5 expression correlates to fibronectin attachment potential whereas integrin ?3 expression correlates with resistance to anoikis and invasion potential. Finally, we demonstrate that expression of miR-145 in esophageal adenocarcinoma cell line (SK-GT-4) enhances tumor growth and metastasis in a NOD/SCID xenograft model. Overall, the oncogenic potential of miR-145 in EAC appears to be mediated by downregulation of c-Myc leading to the expression of integrins subunits ?5 and ?3. ämiR-145 expression enhances integrin expression in SK-GT-4 cell line b(epmc).pdf DeepDyve Pubget Overpricing