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10.1038/ijo.2017.231 http://scihub22266oqcxt.onion/10.1038/ijo.2017.231 C5880581!5880581!28990588     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Obes+(Lond) 2018 ; 42 (3): 391-7 Nephropedia Template TP {{tp|p=28990588|t=2018. Triglycerides cross the blood?brain barrier and induce central leptin and insulin receptor resistance |pdf=|usr=}}{{28990588}} gab.com Text Triglycerides cross the blood brain barrier and induce central leptin and insulin receptor resistance JO: Int J Obes (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=28990588 #FOAvip Objective:: Resistance at the brain receptors for leptin and insulin has been associated with increased feeding, obesity and cognitive impairments. The causal agent for central resistance is unknown but could be derived from the blood. Here we postulate whether hypertriglyceridemia, the major dyslipidemia of the metabolic syndrome, could underlie central leptin and insulin resistance. Design:: We used radioactively labeled triglycerides to measure blood?brain barrier (BBB) penetration, western blots to measure receptor activation, and feeding and cognitive tests to assess behavioral endpoints. Results:: Human CSF was determined to contain triglycerides, a finding previously unclear. The radioactive triglyceride triolein readily crossed the BBB and centrally administered triolein and peripherally administered lipids induced in vivo leptin and/or insulin resistance at hypothalamic receptors. Central triolein blocked the satiety effect of centrally administered leptin. Decreasing serum triglycerides with gemfibrozil improved both learning and memory inversely proportionate to triglyceride levels. Conclusions:: Triglycerides cross the blood?brain barrier rapidly, are found in human cerebrospinal fluid, and induce central leptin and insulin receptor resistance, decreasing satiety and cognition. Twit Text FOAVip Triglycerides cross the blood brain barrier and induce central leptin and insulin receptor resistance ????Int J Obes (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=28990588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28990588 #FOAvip English Wikipedia <ref>{{Cite pmid|28990588}}</ref> Triglycerides cross the blood?brain barrier and induce central leptin and insulin receptor resistance #MMPMID28990588 Banks WA; Farr SA; Salameh TS; Niehoff ML; Rhea EM; Morley JE; Hanson AJ; Hansen KM; Craft S Int J Obes (Lond) 2018[Mar]; 42 (3): 391-7 PMID28990588show ga Objective:: Resistance at the brain receptors for leptin and insulin has been associated with increased feeding, obesity and cognitive impairments. The causal agent for central resistance is unknown but could be derived from the blood. Here we postulate whether hypertriglyceridemia, the major dyslipidemia of the metabolic syndrome, could underlie central leptin and insulin resistance. Design:: We used radioactively labeled triglycerides to measure blood?brain barrier (BBB) penetration, western blots to measure receptor activation, and feeding and cognitive tests to assess behavioral endpoints. Results:: Human CSF was determined to contain triglycerides, a finding previously unclear. The radioactive triglyceride triolein readily crossed the BBB and centrally administered triolein and peripherally administered lipids induced in vivo leptin and/or insulin resistance at hypothalamic receptors. Central triolein blocked the satiety effect of centrally administered leptin. Decreasing serum triglycerides with gemfibrozil improved both learning and memory inversely proportionate to triglyceride levels. Conclusions:: Triglycerides cross the blood?brain barrier rapidly, are found in human cerebrospinal fluid, and induce central leptin and insulin receptor resistance, decreasing satiety and cognition. äTriglycerides cross the blood?brain barrier and induce central leptin (epmc).pdf DeepDyve Pubget Overpricing