Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/978-1-4939-7201-2_15 http://scihub22266oqcxt.onion/10.1007/978-1-4939-7201-2_15 C5880202!5880202 !28809006     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28809006 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28809006 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Methods+Mol+Biol 2017 ; 1647 (ä): 221-236 Nephropedia Template TP {{tp|p=28809006 |t=2017. Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows |pdf=|usr=}}{{28809006 }} gab.com Text Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows JO: Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28809006 #FOAvip We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot spots, incorporating chemical similarity and bioactivity data, and sampling similar binding sites from homologous protein complexes. We demonstrate how to combine existing interdisciplinary resources with examples of semi-automated workflows. Finally, we discuss several major problems, including the occurrence of drug-resistant mutations, drug promiscuity, and the design of dual-effect inhibitors. Twit Text FOAVip Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows ????Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28809006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28809006 #FOAvip English Wikipedia <ref>{{Cite pmid|28809006 }}</ref> Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows #MMPMID28809006 Goncearenco A ; Li M ; Simonetti FL ; Shoemaker BA ; Panchenko AR Methods Mol Biol 2017[]; 1647 (ä): 221-236 PMID28809006 show ga We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot spots, incorporating chemical similarity and bioactivity data, and sampling similar binding sites from homologous protein complexes. We demonstrate how to combine existing interdisciplinary resources with examples of semi-automated workflows. Finally, we discuss several major problems, including the occurrence of drug-resistant mutations, drug promiscuity, and the design of dual-effect inhibitors. |*Drug Design [MESH] |*Molecular Targeted Therapy [MESH] |*Protein Interaction Mapping [MESH] |Antineoplastic Agents/chemistry/*pharmacology [MESH] |Binding Sites [MESH] |Computer Simulation [MESH] |Drug Resistance, Neoplasm [MESH] |Humans [MESH] |Models, Molecular [MESH] |Protein Binding [MESH] |Protein Conformation [MESH] |Proteins/*chemistry [MESH] |Proto-Oncogene Proteins c-mdm2/chemistry/metabolism [MESH] |Tumor Suppressor Protein p53/chemistry/metabolism [MESH]Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer(epmc).pdf DeepDyve Pubget Overpricing