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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Pediatr 2018 ; 18 (ä): ä Nephropedia Template TP
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Number of cholangitis episodes as a prognostic marker to predict timing of liver transplantation in biliary atresia patients after Kasai portoenterostomy #MMPMID29606115
Chen SY; Lin CC; Tsan YT; Chan WC; Wang JD; Chou YJ; Lin CH
BMC Pediatr 2018[]; 18 (ä): ä PMID29606115show ga
Background: Cholangitis may affect liver failure of biliary atresia (BA) patients after Kasai portoenterostomy (KP). We examined whether the number of cholangitis episodes could be a prognostic marker for liver transplant (LT) in children with BA after Kasai portoenterostomy (KP). Methods: Data for BA patients born after 1998 and undergoing KP were obtained from National Health Insurance Research Database (NHIRD), Taiwan. Patients were followed up until the end of 2011. Incidence and the number of cholangitis episodes were recorded and compared between patients based on LT status. Results: Ninety-six (26.8%) of the 366 BA patients underwent LT. More patients who underwent KP at 60 days of age survived with their native liver (P?= 0.007). The mean age at first cholangitis was 0.9 years and 0.8 years in the LT and non-LT groups, respectively (P?=?0.868). The cumulative incidence of cholangitis within 2 years after KP did not differ between the groups (hazard ratio 1.2; 95% CI 0.9?1.6). However, the total number of cholangitis episodes was higher in the LT group within 2 years after KP (P?< 0.001). Conclusions: Cholangitis occurrence was not related to LT in the first 2 years after KP in BA patients, but the number of cholangitis episodes could be a prognostic marker for future LT.