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10.1186/s13000-018-0700-5 http://scihub22266oqcxt.onion/10.1186/s13000-018-0700-5 C5880016!5880016!29606134     free     free     free       Diagn+Pathol 2018 ; 13 (ä): ä Nephropedia Template TP {{tp|p=29606134|t=2018. TGR5 expression in normal kidney and renal neoplasms |pdf=|usr=}}{{29606134}} gab.com Text TGR5 expression in normal kidney and renal neoplasms JO: Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=29606134 #FOAvip Background: The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 is found in a wide variety of tissues including the kidney. However, the patterns of TGR5 expression have not been well characterized in physiologic kidney or renal neoplasms. We explore the expression of TGR5 in benign renal tissue and renal neoplasms and assess its utility as a diagnostic marker. Methods: Sixty-one renal cortical neoplasms from 2000 to 2014 were retrieved. TGR5 protein expression was examined by immunohistochemistry. TGR5 mRNA was also measured by real-time PCR. Results: In normal renal tissue, TGR5 was strongly positive in collecting ducts, distal convoluted tubules and thin loop of Henle. Proximal convoluted tubules showed absent or focal weak staining. In clear cell renal cell carcinomas (RCCs), 25 of 27 cases (92%) were negative for TGR5 (p?<?0.001). TGR5 mRNA was also significantly decreased in clear cell RCCs, suggesting that decreased TGR5 protein expression may be attributable to the downregulation of TGR5 mRNA in these tumors. All 11 papillary RCCs expressed TGR5 with 45% (5/11) exhibiting moderate to strong staining. All chromophobe RCCs and oncocytomas were positive for TGR5 with weak to moderate staining. TGR5 mRNA expression in these tumors was similar to normal kidney. All urothelial carcinomas of the renal pelvis strongly expressed TGR5 including a poorly differentiated urothelial carcinoma with sarcomatoid features. Conclusion: TGR5 is strongly expressed in collecting ducts, distal convoluted tubules and thin loop of Henle. TGR5 protein and mRNA expression were notably decreased in clear cell RCCs and may be helpful in differentiating these tumors from other RCCs. Twit Text FOAVip TGR5 expression in normal kidney and renal neoplasms ????Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=29606134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29606134 #FOAvip English Wikipedia <ref>{{Cite pmid|29606134}}</ref> TGR5 expression in normal kidney and renal neoplasms #MMPMID29606134 Zhao CL; Amin A; Hui Y; Yang D; Cao W Diagn Pathol 2018[]; 13 (ä): ä PMID29606134show ga Background: The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 is found in a wide variety of tissues including the kidney. However, the patterns of TGR5 expression have not been well characterized in physiologic kidney or renal neoplasms. We explore the expression of TGR5 in benign renal tissue and renal neoplasms and assess its utility as a diagnostic marker. Methods: Sixty-one renal cortical neoplasms from 2000 to 2014 were retrieved. TGR5 protein expression was examined by immunohistochemistry. TGR5 mRNA was also measured by real-time PCR. Results: In normal renal tissue, TGR5 was strongly positive in collecting ducts, distal convoluted tubules and thin loop of Henle. Proximal convoluted tubules showed absent or focal weak staining. In clear cell renal cell carcinomas (RCCs), 25 of 27 cases (92%) were negative for TGR5 (p? äTGR5 expression in normal kidney and renal neoplasms (epmc).pdf DeepDyve Pubget Overpricing