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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Retrovirology
2018 ; 15
(1
): 28
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Why was PERV not transmitted during preclinical and clinical xenotransplantation
trials and after inoculation of animals?
#MMPMID29609635
Denner J
Retrovirology
2018[Apr]; 15
(1
): 28
PMID29609635
show ga
Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs,
they infect certain human cells and therefore pose a special risk for
xenotransplantation using pig cells, tissues and organs. Xenotransplantation is
being developed in order to alleviate the reduced availability of human organs.
Despite the fact that PERVs are able to infect certain human cells and cells from
other species, transmission of PERVs has not been observed when animals
(including non-human primates) were inoculated with PERV preparations or during
preclinical xenotransplantations. The data indicate that PERVs were not
transmitted because they were not released from the transplant or were inhibited
by intracellular restriction factors and innate immunity in the recipient. In a
single study in guinea pigs, a transient PERV infection and anti-PERV antibodies
were described, indicating that in this case at least, the immune system may also
have been involved.