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10.1111/1759-7714.12612 http://scihub22266oqcxt.onion/10.1111/1759-7714.12612 C5879053!5879053!29524309     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thorac+Cancer 2018 ; 9 (4): 472-9 Nephropedia Template TP {{tp|p=29524309|t=2018. MiR?577 suppresses epithelial?mesenchymal transition and metastasis of breast cancer by targeting Rab25 |pdf=|usr=}}{{29524309}} gab.com Text MiR 577 suppresses epithelial mesenchymal transition and metastasis of breast cancer by targeting Rab25 JO: Thorac Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29524309 #FOAvip Background: MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR?577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to investigate the effect of miR?577 on breast cancer (BC). Methods: The relative level of miR?577 in 120 BC tissues and cells was detected by real?time PCR. MDA?MB?231 cells with upregulated miR?577 and MCF?7 cells with downregulated miR?577 were established. Transwell invasion assays were used to examine the invasiveness of cells. Epithelial?mesenchymal transition (EMT) markers were evaluated by immunofluorescence and Western blot. Targeted combinations of miR?577 and Rab25 were analyzed by luciferase assays. Xenograft models were used to examine the effect of miR?577 on BC metastasis. Results: MiR?577 expression was significantly suppressed in BC tissues. Tumor size, tumor stage, and lymphatic metastasis were attributed to miR?577 expression. Moreover, miR?577 overexpression strongly inhibited the invasiveness and EMT of BC cells in vitro. MiR?577 directly regulated Rab25 in BC. Rab25 upregulation by miR?577 decreased the levels of E?cadherin and increased the levels of Vimentin. Notably, Rab25 knockdown inhibited BC invasion; however, an increase in Rab25 counteracted the invasive effect of miR?577 in BC. Conclusion: Results indicated that miR?577 suppressed EMT by inhibiting Rab25 expression in BC. MiR?577 and Rab25 are considered potential targets of BC treatment. Twit Text FOAVip MiR 577 suppresses epithelial mesenchymal transition and metastasis of breast cancer by targeting Rab25 ????Thorac Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29524309 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29524309 #FOAvip English Wikipedia <ref>{{Cite pmid|29524309}}</ref> MiR?577 suppresses epithelial?mesenchymal transition and metastasis of breast cancer by targeting Rab25 #MMPMID29524309 Yin C; Mou Q; Pan X; Zhang G; Li H; Sun Y Thorac Cancer 2018[Apr]; 9 (4): 472-9 PMID29524309show ga Background: MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR?577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to investigate the effect of miR?577 on breast cancer (BC). Methods: The relative level of miR?577 in 120 BC tissues and cells was detected by real?time PCR. MDA?MB?231 cells with upregulated miR?577 and MCF?7 cells with downregulated miR?577 were established. Transwell invasion assays were used to examine the invasiveness of cells. Epithelial?mesenchymal transition (EMT) markers were evaluated by immunofluorescence and Western blot. Targeted combinations of miR?577 and Rab25 were analyzed by luciferase assays. Xenograft models were used to examine the effect of miR?577 on BC metastasis. Results: MiR?577 expression was significantly suppressed in BC tissues. Tumor size, tumor stage, and lymphatic metastasis were attributed to miR?577 expression. Moreover, miR?577 overexpression strongly inhibited the invasiveness and EMT of BC cells in vitro. MiR?577 directly regulated Rab25 in BC. Rab25 upregulation by miR?577 decreased the levels of E?cadherin and increased the levels of Vimentin. Notably, Rab25 knockdown inhibited BC invasion; however, an increase in Rab25 counteracted the invasive effect of miR?577 in BC. Conclusion: Results indicated that miR?577 suppressed EMT by inhibiting Rab25 expression in BC. MiR?577 and Rab25 are considered potential targets of BC treatment. äMiR?577 suppresses epithelial?mesenchymal transition and metastasis of(epmc).pdf DeepDyve Pubget Overpricing