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10.1111/j.1463-1326.2007.00784.x http://scihub22266oqcxt.onion/10.1111/j.1463-1326.2007.00784.x C5878925!5878925!17919183     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Obes+Metab 2007 ; 9 (Suppl 2): 89-98 Nephropedia Template TP {{tp|p=17919183|t=2007. Action potentials and insulin secretion: new insights into the role of Kv channels |pdf=|usr=}}{{17919183}} gab.com Text Action potentials and insulin secretion: new insights into the role of Kv channels JO: Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=17919183 #FOAvip Coordinated electrical activity allows pancreatic ?-cells to respond to secretagogues with calcium entry followed by insulin secretion. Metabolism of glucose affects multiple membrane proteins including ion channels, transporters and pumps that collaborate in a cascade of electrical activity resulting in insulin release. Glucose induces ?-cell depolarization resulting in the firing of action potentials (APs), which are the primary electrical signal of the ?-cell. They are shaped by orchestrated activation of ion channels. Here we give an overview of the voltage-gated potassium (Kv) channels of the ?-cell, which are responsible in part for the falling phase of the AP, and how their regulation affects insulin secretion. ? cells contain several Kv channels allowing dynamic integration of multiple signals on repolarization of glucose-stimulated APs. Recent studies on Kv channel regulation by cAMP and arachidonic acid and on the Kv2.1 null mouse have greatly increased our understanding of ?-cell excitation?secretion coupling. Twit Text FOAVip Action potentials and insulin secretion: new insights into the role of Kv channels ????Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=17919183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17919183 #FOAvip English Wikipedia <ref>{{Cite pmid|17919183}}</ref> Action potentials and insulin secretion: new insights into the role of Kv channels #MMPMID17919183 Jacobson DA; Philipson LH Diabetes Obes Metab 2007[Nov]; 9 (Suppl 2): 89-98 PMID17919183show ga Coordinated electrical activity allows pancreatic ?-cells to respond to secretagogues with calcium entry followed by insulin secretion. Metabolism of glucose affects multiple membrane proteins including ion channels, transporters and pumps that collaborate in a cascade of electrical activity resulting in insulin release. Glucose induces ?-cell depolarization resulting in the firing of action potentials (APs), which are the primary electrical signal of the ?-cell. They are shaped by orchestrated activation of ion channels. Here we give an overview of the voltage-gated potassium (Kv) channels of the ?-cell, which are responsible in part for the falling phase of the AP, and how their regulation affects insulin secretion. ? cells contain several Kv channels allowing dynamic integration of multiple signals on repolarization of glucose-stimulated APs. Recent studies on Kv channel regulation by cAMP and arachidonic acid and on the Kv2.1 null mouse have greatly increased our understanding of ?-cell excitation?secretion coupling. äAction potentials and insulin secretion: new insights into the role of(epmc).pdf DeepDyve Pubget Overpricing