Gut 2017 ; 66 (7): 1329-40 Nephropedia Template TP
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CRISPR/Cas9: at the cutting edge of hepatology #MMPMID28487442
Pankowicz FP; Jarrett KE; Lagor WR; Bissig KD
Gut 2017[Jul]; 66 (7): 1329-40 PMID28487442show ga
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the cusp of medical transformation. The therapeutic potential of this technology is tremendous, however, its translation to the clinic will be challenging. In this article, we review recent progress using this genome editing technology and explore its potential uses in studying and treating diseases of the liver. We discuss the development of new research tools and animal models as well as potential clinical applications, strategies and challenges.