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10.1016/j.celrep.2018.02.067 http://scihub22266oqcxt.onion/10.1016/j.celrep.2018.02.067 C5878047!5878047!29539421     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2018 ; 22 (11): 2924-36 Nephropedia Template TP {{tp|p=29539421|t=2018. Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death |pdf=|usr=}}{{29539421}} gab.com Text Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29539421 #FOAvip Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which established GSDMD as a negative regulator of innate immunity. In contrast to its activation in macrophages, in which activated inflammatory caspases cleave GSDMD to produce an N-terminal fragment (GSDMD-cNT) to trigger pyroptosis, GSDMD cleavage and activation in neutrophils was caspase independent. It was mediated by a neutrophil-specific serine protease, neutrophil elastase (ELANE), released from cytoplasmic granules into the cytosol in aging neutrophils. ELANE-mediated GSDMD cleavage was upstream of the caspase cleavage site and produced a fully active ELANE-derived NT fragment (GSDMD-eNT) that induced lytic cell death as efficiently as GSDMD-cNT. Thus, GSDMD is pleiotropic, exerting both pro- and anti-inflammatory effects that make it a potential target for antibacterial and anti-inflammatory therapies. Twit Text FOAVip Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29539421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29539421 #FOAvip English Wikipedia <ref>{{Cite pmid|29539421}}</ref> Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death #MMPMID29539421 Kambara H; Liu F; Zhang X; Liu P; Bajrami B; Teng Y; Zhao L; Zhou S; Yu H; Zhou W; Silberstein LE; Cheng T; Han M; Xu Y; Luo HR Cell Rep 2018[Mar]; 22 (11): 2924-36 PMID29539421show ga Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which established GSDMD as a negative regulator of innate immunity. In contrast to its activation in macrophages, in which activated inflammatory caspases cleave GSDMD to produce an N-terminal fragment (GSDMD-cNT) to trigger pyroptosis, GSDMD cleavage and activation in neutrophils was caspase independent. It was mediated by a neutrophil-specific serine protease, neutrophil elastase (ELANE), released from cytoplasmic granules into the cytosol in aging neutrophils. ELANE-mediated GSDMD cleavage was upstream of the caspase cleavage site and produced a fully active ELANE-derived NT fragment (GSDMD-eNT) that induced lytic cell death as efficiently as GSDMD-cNT. Thus, GSDMD is pleiotropic, exerting both pro- and anti-inflammatory effects that make it a potential target for antibacterial and anti-inflammatory therapies. äGasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil D(epmc).pdf DeepDyve Pubget Overpricing