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10.3390/ijms19030902 http://scihub22266oqcxt.onion/10.3390/ijms19030902 C5877763!5877763!29562663     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (3): ä Nephropedia Template TP {{tp|p=29562663|t=2018. Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection |pdf=|usr=}}{{29562663}} gab.com Text Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29562663 #FOAvip BK polyomavirus (BKPyV; hereafter referred to as BK) causes a lifelong chronic infection and is associated with debilitating disease in kidney transplant recipients. Despite its importance, aspects of the virus life cycle remain poorly understood. In addition to the structural proteins, the late region of the BK genome encodes for an auxiliary protein called agnoprotein. Studies on other polyomavirus agnoproteins have suggested that the protein may contribute to virion infectivity. Here, we demonstrate an essential role for agnoprotein in BK virus release. Viruses lacking agnoprotein fail to release from host cells and do not propagate to wild-type levels. Despite this, agnoprotein is not essential for virion infectivity or morphogenesis. Instead, agnoprotein expression correlates with nuclear egress of BK virions. We demonstrate that the agnoprotein binding partner ?-soluble N-ethylmaleimide sensitive fusion (NSF) attachment protein (?-SNAP) is necessary for BK virion release, and siRNA knockdown of ?-SNAP prevents nuclear release of wild-type BK virions. These data highlight a novel role for agnoprotein and begin to reveal the mechanism by which polyomaviruses leave an infected cell. Twit Text FOAVip Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29562663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29562663 #FOAvip English Wikipedia <ref>{{Cite pmid|29562663}}</ref> Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection #MMPMID29562663 Panou MM; Prescott EL; Hurdiss DL; Swinscoe G; Hollinshead M; Caller LG; Morgan EL; Carlisle L; Müller M; Antoni M; Kealy D; Ranson NA; Crump CM; Macdonald A Int J Mol Sci 2018[Mar]; 19 (3): ä PMID29562663show ga BK polyomavirus (BKPyV; hereafter referred to as BK) causes a lifelong chronic infection and is associated with debilitating disease in kidney transplant recipients. Despite its importance, aspects of the virus life cycle remain poorly understood. In addition to the structural proteins, the late region of the BK genome encodes for an auxiliary protein called agnoprotein. Studies on other polyomavirus agnoproteins have suggested that the protein may contribute to virion infectivity. Here, we demonstrate an essential role for agnoprotein in BK virus release. Viruses lacking agnoprotein fail to release from host cells and do not propagate to wild-type levels. Despite this, agnoprotein is not essential for virion infectivity or morphogenesis. Instead, agnoprotein expression correlates with nuclear egress of BK virions. We demonstrate that the agnoprotein binding partner ?-soluble N-ethylmaleimide sensitive fusion (NSF) attachment protein (?-SNAP) is necessary for BK virion release, and siRNA knockdown of ?-SNAP prevents nuclear release of wild-type BK virions. These data highlight a novel role for agnoprotein and begin to reveal the mechanism by which polyomaviruses leave an infected cell. äAgnoprotein Is an Essential Egress Factor during BK Polyomavirus Infec(epmc).pdf DeepDyve Pubget Overpricing