Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29547524
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29547524
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Mol+Sci
2018 ; 19
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates
Myocardial Ischemia/Reperfusion Injury in Mice
#MMPMID29547524
Chadani H
; Usui S
; Inoue O
; Kusayama T
; Takashima SI
; Kato T
; Murai H
; Furusho H
; Nomura A
; Misu H
; Takamura T
; Kaneko S
; Takamura M
Int J Mol Sci
2018[Mar]; 19
(3
): ä PMID29547524
show ga
Selenoprotein P (SeP), a liver-derived secretory protein, functions as a selenium
supply protein in the body. SeP has been reported to be associated with insulin
resistance in humans through serial analysis of gene expression. Recently, SeP
has been found to inhibit vascular endothelial growth factor-stimulated cell
proliferation in human umbilical vein endothelial cells, and impair angiogenesis
in a mouse hind limb model. In this study, the role of SeP in
ischemia/reperfusion (I/R) injury has been investigated. SeP knockout (KO) and
littermate wild-type (WT) mice were subjected to 30 min of myocardial ischemia
followed by 24 h of reperfusion. The myocardial infarct area/area at risk
(IA/AAR), evaluated using Evans blue (EB) and 2,3,5-triphenyltetrazolium chloride
(TTC) staining, was significantly smaller in SeP KO mice than in WT mice. The
number of terminal de-oxynucleotidyl transferase dUTP nick end labeling
(TUNEL)-positive nuclei was significantly lower in SeP KO mice than in WT mice.
In addition, caspase-3 activation was reduced in SeP KO mice compared to that in
WT mice. Furthermore, phosphoinositide 3-kinase/Akt and Erk levels were examined
for the reperfusion injury salvage kinase (RISK) pathway. Interestingly, SeP KO
significantly increased the phosphorylation of IGF-1, Akt, and Erk compared to
that in WT mice after I/R. Finally, I/R-induced myocardial IA/AAR was
significantly increased in SeP KO mice overexpressing SeP in the liver compared
to other SeP KO mice. These results, together, suggest that inhibition of SeP
protects the heart from I/R injury through upregulation of the RISK pathway.
free
free
free
