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10.3390/ijms19030818 http://scihub22266oqcxt.onion/10.3390/ijms19030818 C5877679!5877679!29534520     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (3): ä Nephropedia Template TP {{tp|p=29534520|t=2018. mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome |pdf=|usr=}}{{29534520}} gab.com Text mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29534520 #FOAvip The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and metabolism with environmental inputs to ensure that cells grow only under favourable conditions. When active, mTORC1 stimulates biosynthetic pathways including protein, lipid and nucleotide synthesis and inhibits cellular catabolism through repression of the autophagic pathway, thereby promoting cell growth and proliferation. The recruitment of mTORC1 to the lysosomal surface has been shown to be essential for its activation. This finding has significantly enhanced our knowledge of mTORC1 regulation and has focused the attention of the field on the lysosome as a signalling hub which coordinates several homeostatic pathways. The intriguing localisation of mTORC1 to the cellular organelle that plays a crucial role in catabolism enables mTORC1 to feedback to autophagy and lysosomal biogenesis, thus leading mTORC1 to enact precise spatial and temporal control of cell growth. This review will cover the signalling interactions which take place on the surface of lysosomes and the cross-talk which exists between mTORC1 activity and lysosomal function. Twit Text FOAVip mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29534520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29534520 #FOAvip English Wikipedia <ref>{{Cite pmid|29534520}}</ref> mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome #MMPMID29534520 Rabanal-Ruiz Y; Korolchuk VI Int J Mol Sci 2018[Mar]; 19 (3): ä PMID29534520show ga The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and metabolism with environmental inputs to ensure that cells grow only under favourable conditions. When active, mTORC1 stimulates biosynthetic pathways including protein, lipid and nucleotide synthesis and inhibits cellular catabolism through repression of the autophagic pathway, thereby promoting cell growth and proliferation. The recruitment of mTORC1 to the lysosomal surface has been shown to be essential for its activation. This finding has significantly enhanced our knowledge of mTORC1 regulation and has focused the attention of the field on the lysosome as a signalling hub which coordinates several homeostatic pathways. The intriguing localisation of mTORC1 to the cellular organelle that plays a crucial role in catabolism enables mTORC1 to feedback to autophagy and lysosomal biogenesis, thus leading mTORC1 to enact precise spatial and temporal control of cell growth. This review will cover the signalling interactions which take place on the surface of lysosomes and the cross-talk which exists between mTORC1 activity and lysosomal function. ämTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome (epmc).pdf DeepDyve Pubget Overpricing