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10.3390/ijms19030688 http://scihub22266oqcxt.onion/10.3390/ijms19030688 C5877549!5877549!29495593     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (3): ä Nephropedia Template TP {{tp|p=29495593|t=2018. Advances in the Genetics of Hypertension: The Effect of Rare Variants |pdf=|usr=}}{{29495593}} gab.com Text Advances in the Genetics of Hypertension: The Effect of Rare Variants JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29495593 #FOAvip Worldwide, hypertension still represents a serious health burden with nine million people dying as a consequence of hypertension-related complications. Essential hypertension is a complex trait supported by multifactorial genetic inheritance together with environmental factors. The heritability of blood pressure (BP) is estimated to be 30?50%. A great effort was made to find genetic variants affecting BP levels through Genome-Wide Association Studies (GWAS). This approach relies on the ?common disease?common variant? hypothesis and led to the identification of multiple genetic variants which explain, in aggregate, only 2?3% of the genetic variance of hypertension. Part of the missing genetic information could be caused by variants too rare to be detected by GWAS. The use of exome chips and Next-Generation Sequencing facilitated the discovery of causative variants. Here, we report the advances in the detection of novel rare variants, genes, and/or pathways through the most promising approaches, and the recent statistical tests that have emerged to handle rare variants. We also discuss the need to further support rare novel variants with replication studies within larger consortia and with deeper functional studies to better understand how new genes might improve patient care and the stratification of the response to antihypertensive treatments. Twit Text FOAVip Advances in the Genetics of Hypertension: The Effect of Rare Variants ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29495593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29495593 #FOAvip English Wikipedia <ref>{{Cite pmid|29495593}}</ref> Advances in the Genetics of Hypertension: The Effect of Rare Variants #MMPMID29495593 Russo A; Di Gaetano C; Cugliari G; Matullo G Int J Mol Sci 2018[Mar]; 19 (3): ä PMID29495593show ga Worldwide, hypertension still represents a serious health burden with nine million people dying as a consequence of hypertension-related complications. Essential hypertension is a complex trait supported by multifactorial genetic inheritance together with environmental factors. The heritability of blood pressure (BP) is estimated to be 30?50%. A great effort was made to find genetic variants affecting BP levels through Genome-Wide Association Studies (GWAS). This approach relies on the ?common disease?common variant? hypothesis and led to the identification of multiple genetic variants which explain, in aggregate, only 2?3% of the genetic variance of hypertension. Part of the missing genetic information could be caused by variants too rare to be detected by GWAS. The use of exome chips and Next-Generation Sequencing facilitated the discovery of causative variants. Here, we report the advances in the detection of novel rare variants, genes, and/or pathways through the most promising approaches, and the recent statistical tests that have emerged to handle rare variants. We also discuss the need to further support rare novel variants with replication studies within larger consortia and with deeper functional studies to better understand how new genes might improve patient care and the stratification of the response to antihypertensive treatments. äAdvances in the Genetics of Hypertension: The Effect of Rare Variants (epmc).pdf DeepDyve Pubget Overpricing