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10.3390/ijms19030653 http://scihub22266oqcxt.onion/10.3390/ijms19030653 C5877514!5877514!29495367     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2018 ; 19 (3): ä Nephropedia Template TP {{tp|p=29495367|t=2018. The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis |pdf=|usr=}}{{29495367}} gab.com Text The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29495367 #FOAvip Expression of aquaporin-1 (AQP1) in endothelial cells is critical for their migration and angiogenesis in cancer. We tested the AQP1 inhibitor, bacopaside II, derived from medicinal plant Bacopa monnieri, on endothelial cell migration and tube-formation in vitro using mouse endothelial cell lines (2H11 and 3B11) and human umbilical vein endothelial cells (HUVEC). The effect of bacopaside II on viability, apoptosis, migration and tubulogenesis was assessed by a proliferation assay, annexin-V/propidium iodide flow cytometry, the scratch wound assay and endothelial tube-formation, respectively. Cell viability was reduced significantly for 2H11 at 15 ?M (p = 0.037), 3B11 at 12.5 ?M (p = 0.017) and HUVEC at 10 ?M (p < 0.0001). At 15 ?M, the reduced viability was accompanied by an increase in apoptosis of 38%, 50% and 32% for 2H11, 3B11 and HUVEC, respectively. Bacopaside II at ?10 ?M significantly reduced migration of 2H11 (p = 0.0002) and 3B11 (p = 0.034). HUVECs were most sensitive with a significant reduction at ?7.5 ?M (p = 0.037). Tube-formation was reduced with a 15 ?M dose for all cell lines and 10 ?M for 3B11 (p < 0.0001). These results suggest that bacopaside II is a potential anti-angiogenic agent. Twit Text FOAVip The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29495367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29495367 #FOAvip English Wikipedia <ref>{{Cite pmid|29495367}}</ref> The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis #MMPMID29495367 Palethorpe HM; Tomita Y; Smith E; Pei JV; Townsend AR; Price TJ; Young JP; Yool AJ; Hardingham JE Int J Mol Sci 2018[Mar]; 19 (3): ä PMID29495367show ga Expression of aquaporin-1 (AQP1) in endothelial cells is critical for their migration and angiogenesis in cancer. We tested the AQP1 inhibitor, bacopaside II, derived from medicinal plant Bacopa monnieri, on endothelial cell migration and tube-formation in vitro using mouse endothelial cell lines (2H11 and 3B11) and human umbilical vein endothelial cells (HUVEC). The effect of bacopaside II on viability, apoptosis, migration and tubulogenesis was assessed by a proliferation assay, annexin-V/propidium iodide flow cytometry, the scratch wound assay and endothelial tube-formation, respectively. Cell viability was reduced significantly for 2H11 at 15 ?M (p = 0.037), 3B11 at 12.5 ?M (p = 0.017) and HUVEC at 10 ?M (p < 0.0001). At 15 ?M, the reduced viability was accompanied by an increase in apoptosis of 38%, 50% and 32% for 2H11, 3B11 and HUVEC, respectively. Bacopaside II at ?10 ?M significantly reduced migration of 2H11 (p = 0.0002) and 3B11 (p = 0.034). HUVECs were most sensitive with a significant reduction at ?7.5 ?M (p = 0.037). Tube-formation was reduced with a 15 ?M dose for all cell lines and 10 ?M for 3B11 (p < 0.0001). These results suggest that bacopaside II is a potential anti-angiogenic agent. äThe Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migra(epmc).pdf DeepDyve Pubget Overpricing