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10.2147/LCTT.S124483

http://scihub22266oqcxt.onion/10.2147/LCTT.S124483
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C5877502!5877502!29628779
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pmid29628779      Lung+Cancer+(Auckl) 2018 ; 9 (ä): 35-43
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  • Role and inhibition of GLI1 protein in cancer #MMPMID29628779
  • Mastrangelo E; Milani M
  • Lung Cancer (Auckl) 2018[]; 9 (ä): 35-43 PMID29628779show ga
  • GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non?small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies.
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