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10.2174/1381612824666171227222624

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suck abstract from ncbi


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pmid29283058      Curr+Pharm+Des 2018 ; 24 (1): 78-83
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  • Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy #MMPMID29283058
  • Ren YB; Sun SJ; Han SY
  • Curr Pharm Des 2018[Jan]; 24 (1): 78-83 PMID29283058show ga
  • T-cell therapy using genetically engineered T cells modified with either T cell receptor or chi-meric antigen receptor holds great promise for cancer immunotherapy. The concerns about its toxicities still remain despite recent successes in clinical trials. Temporal and spatial control of the engineered therapeutic T cells may improve the safety profile of these treatment regimens. To achieve these goals, numerous approaches have been tested and utilized including the incorporation of a suicide gene, the switch-mediated activation, the combinatorial antigen recognition, etc. This review will summarize the toxicities caused by engineered T cells and novel strategies to overcome them.
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