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10.1186/s41236-017-0004-9 http://scihub22266oqcxt.onion/10.1186/s41236-017-0004-9 C5876692!5876692!29623954     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Converg 2017 ; 1 (1): ä Nephropedia Template TP {{tp|p=29623954|t=2017. Probing three-dimensional collective cancer invasion with DIGME |pdf=|usr=}}{{29623954}} gab.com Text Probing three-dimensional collective cancer invasion with DIGME JO: Cancer Converg http://www.kidney.de/pget.php?&tw=1&pmid=29623954 #FOAvip Background: Multicellular pattern formation plays an important role in developmental biology, cancer metastasis and wound healing. While many physical factors have been shown to regulate these multicellular processes, the role of ECM micro-to-meso scale geometry has been poorly understood in 3D collective cancer invasion. Results: We have developed a mechanical-based strategy, Diskoid In Geometrically Micropatterned ECM (DIGME). DIGME allows easy engineering of the shape of 3D tissue organoid, the mesoscale ECM heterogeneity, and the fiber alignment of collagen-based ECM all at the same time. We have employed DIGME to study the 3D invasion of MDA-MB-231 diskoids in engineered collagen matrix. We find that the collective cancer invasion is closely regulated by the micro-to-meso scale geometry of the ECM. Conclusions: We conclude that DIGME provides a simple yet powerful tool to probe 3D dynamics of tissue organoids in physically patterned microenvironments. Electronic supplementary material: The online version of this article (doi:10.1186/s41236-017-0004-9) contains supplementary material, which is available to authorized users. Twit Text FOAVip Probing three-dimensional collective cancer invasion with DIGME ????Cancer Converg http://www.kidney.de/pget.php?&tw=1&pmid=29623954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29623954 #FOAvip English Wikipedia <ref>{{Cite pmid|29623954}}</ref> Probing three-dimensional collective cancer invasion with DIGME #MMPMID29623954 Alobaidi AA; Sun B Cancer Converg 2017[]; 1 (1): ä PMID29623954show ga Background: Multicellular pattern formation plays an important role in developmental biology, cancer metastasis and wound healing. While many physical factors have been shown to regulate these multicellular processes, the role of ECM micro-to-meso scale geometry has been poorly understood in 3D collective cancer invasion. Results: We have developed a mechanical-based strategy, Diskoid In Geometrically Micropatterned ECM (DIGME). DIGME allows easy engineering of the shape of 3D tissue organoid, the mesoscale ECM heterogeneity, and the fiber alignment of collagen-based ECM all at the same time. We have employed DIGME to study the 3D invasion of MDA-MB-231 diskoids in engineered collagen matrix. We find that the collective cancer invasion is closely regulated by the micro-to-meso scale geometry of the ECM. Conclusions: We conclude that DIGME provides a simple yet powerful tool to probe 3D dynamics of tissue organoids in physically patterned microenvironments. Electronic supplementary material: The online version of this article (doi:10.1186/s41236-017-0004-9) contains supplementary material, which is available to authorized users. äProbing three-dimensional collective cancer invasion with DIGME (epmc).pdf DeepDyve Pubget Overpricing