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2018 ; 10
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer:
Understanding Disease Progression and What We Can Do to Prevent It
#MMPMID29558443
Armstrong H
; Bording-Jorgensen M
; Dijk S
; Wine E
Cancers (Basel)
2018[Mar]; 10
(3
): ä PMID29558443
show ga
Cancer is a multifaceted condition, in which a senescent cell begins dividing in
an irregular manner due to various factors such as DNA damage, growth factors and
inflammation. Inflammation is not typically discussed as carcinogenic; however, a
significant percentage of cancers arise from chronic microbial infections and
damage brought on by chronic inflammation. A hallmark cancer-inducing microbe is
Helicobacter pylori and its causation of peptic ulcers and potentially gastric
cancer. This review discusses the recent developments in understanding microbes
in health and disease and their potential role in the progression of cancer. To
date, microbes can be linked to almost every cancer, including colon, pancreatic,
gastric, and even prostate. We discuss the known mechanisms by which these
microbes can induce cancer growth and development and how inflammatory cells may
contribute to cancer progression. We also discuss new treatments that target the
chronic inflammatory conditions and their associated cancers, and the impact
microbes have on treatment success. Finally, we examine common dietary
misconceptions in relation to microbes and cancer and how to avoid getting caught
up in the misinterpretation and over inflation of the results.