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10.1038/s41598-018-23620-y http://scihub22266oqcxt.onion/10.1038/s41598-018-23620-y C5876347!5876347!29599471     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29599471|t=2018. Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation |pdf=|usr=}}{{29599471}} gab.com Text Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29599471 #FOAvip We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function in functional dyspepsia (FD). We aimed to further describe the implication of these immune cells by assessing their activation state at the ultrastructural level and by evaluating the association between impaired epithelial integrity and immune activation. Duodenal biopsies were obtained from 24 FD patients and 37 healthy controls. The ultrastructure of mast cells and eosinophils was analyzed by transmission electron microscopy. Transepithelial electrical resistance and paracellular permeability were measured to evaluate epithelial barrier function. The type of degranulation in eosinophils and mast cells was piecemeal. Eosinophils displayed higher degree of degranulation in FD patients than in controls (p?<?0.0001). Quantification revealed a decreased granular density in eosinophils of FD patients (p?<?0.0001). The degree of degranulation in mast cells was similar in both groups. However, a more heterogeneous profile was found in the FD group (p?<?0.0001). No association between epithelial integrity and the number and activation state of mucosal eosinophils and mast cells was found. We demonstrated ultrastructural changes in degranulation state of eosinophils and mast cells, suggesting that eosinophil and mast cell activation play a role in the pathophysiology of FD. Twit Text FOAVip Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29599471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29599471 #FOAvip English Wikipedia <ref>{{Cite pmid|29599471}}</ref> Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation #MMPMID29599471 Vanheel H; Vicario M; Boesmans W; Vanuytsel T; Salvo-Romero E; Tack J; Farré R Sci Rep 2018[]; 8 (ä): ä PMID29599471show ga We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function in functional dyspepsia (FD). We aimed to further describe the implication of these immune cells by assessing their activation state at the ultrastructural level and by evaluating the association between impaired epithelial integrity and immune activation. Duodenal biopsies were obtained from 24 FD patients and 37 healthy controls. The ultrastructure of mast cells and eosinophils was analyzed by transmission electron microscopy. Transepithelial electrical resistance and paracellular permeability were measured to evaluate epithelial barrier function. The type of degranulation in eosinophils and mast cells was piecemeal. Eosinophils displayed higher degree of degranulation in FD patients than in controls (p? äActivation of Eosinophils and Mast Cells in Functional Dyspepsia: an U(epmc).pdf DeepDyve Pubget Overpricing