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10.1007/s13238-017-0425-3 http://scihub22266oqcxt.onion/10.1007/s13238-017-0425-3 C5876181!5876181!28540653     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+Cell 2018 ; 9 (4): 322-32 Nephropedia Template TP {{tp|p=28540653|t=2018. IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes |pdf=|usr=}}{{28540653}} gab.com Text IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=28540653 #FOAvip Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-? in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process. Twit Text FOAVip IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=28540653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28540653 #FOAvip English Wikipedia <ref>{{Cite pmid|28540653}}</ref> IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes #MMPMID28540653 Apert C; Romagnoli P; van Meerwijk JPM Protein Cell 2018[Apr]; 9 (4): 322-32 PMID28540653show ga Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-? in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process. äIL-2 and IL-15 dependent thymic development of Foxp3-expressing regula(epmc).pdf DeepDyve Pubget Overpricing