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10.14814/phy2.13654 http://scihub22266oqcxt.onion/10.14814/phy2.13654 C5875544!5875544!29595914     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rep 2018 ; 6 (6): ä Nephropedia Template TP {{tp|p=29595914|t=2018. Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy |pdf=|usr=}}{{29595914}} gab.com Text Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=29595914 #FOAvip Human GWAS and Mendelian genetic studies have linked polymorphic variants and mutations in the human uromodulin gene (UMOD) with chronic kidney disease. The primary function of this kidney?specific and secreted protein remains elusive. This study investigated whether UMOD deficiency modified responses to unilateral ureteral obstruction (UUO)?induced kidney injury. Kidneys harvested from groups of wild?type (UMOD+/+) and knockout (UMOD?/?) male mice (n = 7?10 each) were studied on days 7, 14, and 21. Compared to sham kidneys, UMOD protein levels increased 9?13x after UUO and were associated with increased urinary UMOD levels. Kidney KIM?1 protein levels were higher in the UMOD?/? groups at all time?points (4?14x). The UMOD?/? groups also had higher KIM?1 kidney?to?urine relative ratios (5?35x). In vitro studies using KIM?1 expressing 769?P cells showed lower KIM?1 levels in the presence of UMOD protein. Levels of proapoptotic genes and the epithelial cell apoptotic protein marker M30 were significantly lower in the UMOD?/? groups. Both M30 and KIM?1 colocalized with intraluminal UMOD protein deposits. Interstitial inflammation was less intense in the UMOD?/? groups. Renal fibrosis severity (kidney collagen mRNA and protein) was similar in both genotypic groups on days 7, 14, and 21. Our findings suggest a role for UMOD?dependent inhibition of KIM?1 expression and its apoptotic cell scavenging responses during chronic obstruction?associated tubular injury. Twit Text FOAVip Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=29595914 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29595914 #FOAvip English Wikipedia <ref>{{Cite pmid|29595914}}</ref> Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy #MMPMID29595914 Maydan O; McDade PG; Liu Y; Wu X; Matsell DG; Eddy AA Physiol Rep 2018[Mar]; 6 (6): ä PMID29595914show ga Human GWAS and Mendelian genetic studies have linked polymorphic variants and mutations in the human uromodulin gene (UMOD) with chronic kidney disease. The primary function of this kidney?specific and secreted protein remains elusive. This study investigated whether UMOD deficiency modified responses to unilateral ureteral obstruction (UUO)?induced kidney injury. Kidneys harvested from groups of wild?type (UMOD+/+) and knockout (UMOD?/?) male mice (n = 7?10 each) were studied on days 7, 14, and 21. Compared to sham kidneys, UMOD protein levels increased 9?13x after UUO and were associated with increased urinary UMOD levels. Kidney KIM?1 protein levels were higher in the UMOD?/? groups at all time?points (4?14x). The UMOD?/? groups also had higher KIM?1 kidney?to?urine relative ratios (5?35x). In vitro studies using KIM?1 expressing 769?P cells showed lower KIM?1 levels in the presence of UMOD protein. Levels of proapoptotic genes and the epithelial cell apoptotic protein marker M30 were significantly lower in the UMOD?/? groups. Both M30 and KIM?1 colocalized with intraluminal UMOD protein deposits. Interstitial inflammation was less intense in the UMOD?/? groups. Renal fibrosis severity (kidney collagen mRNA and protein) was similar in both genotypic groups on days 7, 14, and 21. Our findings suggest a role for UMOD?dependent inhibition of KIM?1 expression and its apoptotic cell scavenging responses during chronic obstruction?associated tubular injury. äUromodulin deficiency alters tubular injury and interstitial inflammat(epmc).pdf DeepDyve Pubget Overpricing