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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Emerg+Infect+Dis 2018 ; 24 (4): 654-62 Nephropedia Template TP
Anh NT; Nhu LNT; Van HMT; Hong NTT; Thanh TT; Hang VTT; Ny NTH; Nguyet LA; Phuong TTL; Nhan LNT; Hung NT; Khanh TH; Tuan HM; Viet HL; Nam NT; Viet DC; Qui PT; Wills B; Sabanathan S; Chau NVV; Thwaites L; Rogier van Doorn H; Thwaites G; Rabaa MA; Van Tan L
Emerg Infect Dis 2018[Apr]; 24 (4): 654-62 PMID29553326show ga
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011?2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare. Skyline plots identified fluctuations in the relative genetic diversity of CV-A6 corresponding to large CV-A6?associated HFMD outbreaks worldwide. These data show that CV-A6 is an emerging pathogen and emphasize the necessity of active surveillance and understanding the mechanisms that shape the pathogen evolution and emergence, which is essential for development and implementation of intervention strategies.