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10.1590/S1679-45082017RB4106 http://scihub22266oqcxt.onion/10.1590/S1679-45082017RB4106 C5875170!5875170!29364369     free     free     free       Einstein+(Sao+Paulo) 2017 ; 15 (4): 507-11 Nephropedia Template TP {{tp|p=29364369|t=2017. Regulation of adiposity by mTORC1 |pdf=|usr=}}{{29364369}} gab.com Text Regulation of adiposity by mTORC1 JO: Einstein (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=29364369 #FOAvip Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies. Evidence accumulated over the years indicates that obesity is associated with a marked activation in adipose tissue of the mechanistic target of rapamycin complex 1 (mTORC1), a signaling pathway that controls lipid metabolism, and adipocyte formation and maintenance. Curiously, mTORC1 is also involved in the control of nonshivering thermogenesis and recruitment as well as browning of white adipose tissue. In this review, we explored mTORC1 functions in adipocytes and presented evidence, suggesting that mTORC1 may either increase or reduce adiposity, depending on the conditions and activation levels. Twit Text FOAVip Regulation of adiposity by mTORC1 ????Einstein (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=29364369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29364369 #FOAvip English Wikipedia <ref>{{Cite pmid|29364369}}</ref> Regulation of adiposity by mTORC1 #MMPMID29364369 Magdalon J; Festuccia WT Einstein (Sao Paulo) 2017[Oct]; 15 (4): 507-11 PMID29364369show ga Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies. Evidence accumulated over the years indicates that obesity is associated with a marked activation in adipose tissue of the mechanistic target of rapamycin complex 1 (mTORC1), a signaling pathway that controls lipid metabolism, and adipocyte formation and maintenance. Curiously, mTORC1 is also involved in the control of nonshivering thermogenesis and recruitment as well as browning of white adipose tissue. In this review, we explored mTORC1 functions in adipocytes and presented evidence, suggesting that mTORC1 may either increase or reduce adiposity, depending on the conditions and activation levels. äRegulation of adiposity by mTORC1 (epmc).pdf DeepDyve Pubget Overpricing