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10.1186/s13072-018-0184-2 http://scihub22266oqcxt.onion/10.1186/s13072-018-0184-2 C5875001!5875001!29598828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29598828&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics+Chromatin 2018 ; 11 (ä): ä Nephropedia Template TP {{tp|p=29598828|t=2018. The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally |pdf=|usr=}}{{29598828}} gab.com Text The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally JO: Epigenetics Chromatin http://www.kidney.de/pget.php?&tw=1&pmid=29598828 #FOAvip Background: Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt?Ada?Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and SAGA contribute to the synthesis of nearly all transcripts and are recruited genome-wide in yeast. However, how this broad recruitment confers selectivity under specific conditions remains an open question. Results: Here we find that the SAGA/TREX-2 subunit Sus1 associates with upstream regulatory regions of many yeast genes and that heat shock drastically changes Sus1 binding. While Sus1 binding to TFIID-dominated genes is not affected by temperature, its recruitment to SAGA-dominated genes and RP genes is significantly disturbed under heat shock, with Sus1 relocated to environmental stress-responsive genes in these conditions. Moreover, in contrast to recent results showing that SAGA deubiquitinating enzyme Ubp8 is dispensable for RNA synthesis, genomic run-on experiments demonstrate that Sus1 contributes to synthesis and stability of a wide range of transcripts. Conclusions: Our study provides support for a model in which SAGA/TREX-2 factor Sus1 acts as a global transcriptional regulator in yeast but has differential activity at yeast genes as a function of their transcription rate or during stress conditions. Electronic supplementary material: The online version of this article (10.1186/s13072-018-0184-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally ????Epigenetics Chromatin http://www.kidney.de/pget.php?&tw=1&pmid=29598828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29598828 #FOAvip English Wikipedia <ref>{{Cite pmid|29598828}}</ref> The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally #MMPMID29598828 García-Molinero V; García-Martínez J; Reja R; Furió-Tarí P; Antúnez O; Vinayachandran V; Conesa A; Pugh BF; Pérez-Ortín JE; Rodríguez-Navarro S Epigenetics Chromatin 2018[]; 11 (ä): ä PMID29598828show ga Background: Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt?Ada?Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and SAGA contribute to the synthesis of nearly all transcripts and are recruited genome-wide in yeast. However, how this broad recruitment confers selectivity under specific conditions remains an open question. Results: Here we find that the SAGA/TREX-2 subunit Sus1 associates with upstream regulatory regions of many yeast genes and that heat shock drastically changes Sus1 binding. While Sus1 binding to TFIID-dominated genes is not affected by temperature, its recruitment to SAGA-dominated genes and RP genes is significantly disturbed under heat shock, with Sus1 relocated to environmental stress-responsive genes in these conditions. Moreover, in contrast to recent results showing that SAGA deubiquitinating enzyme Ubp8 is dispensable for RNA synthesis, genomic run-on experiments demonstrate that Sus1 contributes to synthesis and stability of a wide range of transcripts. Conclusions: Our study provides support for a model in which SAGA/TREX-2 factor Sus1 acts as a global transcriptional regulator in yeast but has differential activity at yeast genes as a function of their transcription rate or during stress conditions. Electronic supplementary material: The online version of this article (10.1186/s13072-018-0184-2) contains supplementary material, which is available to authorized users. äThe SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and aff(epmc).pdf DeepDyve Pubget Overpricing