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10.3390/biomedicines6010036 http://scihub22266oqcxt.onion/10.3390/biomedicines6010036 C5874693!5874693 !29562713     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29562713 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Direct and Indirect Roles of NF-?B in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice |pdf=|usr=}}{{29562713 }} gab.com Text The Direct and Indirect Roles of NF- B in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=29562713 #FOAvip NF-?B signaling pathways play an important role in the regulation of cellular immune and stress responses. Aberrant NF-?B activity has been implicated in almost all the steps of cancer development and many of the direct and indirect contributions of this transcription factor system for oncogenesis were revealed in the recent years. The indirect contributions affect almost all hallmarks and enabling characteristics of cancer, but NF-?B can either promote or antagonize these tumor-supportive functions, thus prohibiting global NF-?B inhibition. The direct effects are due to mutations of members of the NF-?B system itself. These mutations typically occur in upstream components that lead to the activation of NF-?B together with further oncogenesis-promoting signaling pathways. In contrast, mutations of the downstream components, such as the DNA-binding subunits, contribute to oncogenic transformation by affecting NF-?B-driven transcriptional output programs. Here, we discuss the features of recently identified oncogenic RelA fusion proteins and the characterization of pathways that are regulating the transcriptional activity of NF-?B by regulatory phosphorylations. As NF-?B's central role in human physiology prohibits its global inhibition, these auxiliary or cell type-specific NF-?B regulating pathways are potential therapeutic targets. Twit Text FOAVip The Direct and Indirect Roles of NF- B in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=29562713 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29562713 #FOAvip English Wikipedia <ref>{{Cite pmid|29562713 }}</ref> The Direct and Indirect Roles of NF-?B in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice #MMPMID29562713 Riedlinger T ; Haas J ; Busch J ; van de Sluis B ; Kracht M ; Schmitz ML Biomedicines 2018[Mar]; 6 (1 ): ä PMID29562713 show ga NF-?B signaling pathways play an important role in the regulation of cellular immune and stress responses. Aberrant NF-?B activity has been implicated in almost all the steps of cancer development and many of the direct and indirect contributions of this transcription factor system for oncogenesis were revealed in the recent years. The indirect contributions affect almost all hallmarks and enabling characteristics of cancer, but NF-?B can either promote or antagonize these tumor-supportive functions, thus prohibiting global NF-?B inhibition. The direct effects are due to mutations of members of the NF-?B system itself. These mutations typically occur in upstream components that lead to the activation of NF-?B together with further oncogenesis-promoting signaling pathways. In contrast, mutations of the downstream components, such as the DNA-binding subunits, contribute to oncogenic transformation by affecting NF-?B-driven transcriptional output programs. Here, we discuss the features of recently identified oncogenic RelA fusion proteins and the characterization of pathways that are regulating the transcriptional activity of NF-?B by regulatory phosphorylations. As NF-?B's central role in human physiology prohibits its global inhibition, these auxiliary or cell type-specific NF-?B regulating pathways are potential therapeutic targets. äThe Direct and Indirect Roles of NF-?B in Cancer: Lessons from Oncogen(epmc).pdf DeepDyve Pubget Overpricing