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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 mSphere 2018 ; 3 (2): ä Nephropedia Template TP
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Investigating Colonization of the Healthy Adult Gastrointestinal Tract by Fungi #MMPMID29600282
Auchtung TA; Fofanova TY; Stewart CJ; Nash AK; Wong MC; Gesell JR; Auchtung JM; Ajami NJ; Petrosino JF
mSphere 2018[Mar]; 3 (2): ä PMID29600282show ga
We sought to identify the fungi that colonize healthy GI tracts and that have a sustained influence on the diverse functions of the gut microbiome. Instead, we found that all fungi in the stool of healthy volunteers could be explained by their presence in oral and dietary sources and that our results, together with those from other analyses, support the model that there is little or no gastrointestinal colonization by fungi. This may be due to Westernization, primate evolution, fungal ecology, and/or the strong defenses of a healthy immune system. Importantly, fungal colonization of the GI tract may often be indicative of disease. As fungi can cause serious infections in immunocompromised individuals and are found at increased abundance in multiple disorders of the GI tract, understanding normal fungal colonization is essential for proper treatment and prevention of fungal pathogenesis.