Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29623258
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29623258
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Cell+Infect+Microbiol
2018 ; 8
(ä): 77
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
From Phagocytes to Immune Defense: Roles for Coronin Proteins in Dictyostelium
and Mammalian Immunity
#MMPMID29623258
Mori M
; Mode R
; Pieters J
Front Cell Infect Microbiol
2018[]; 8
(ä): 77
PMID29623258
show ga
Microbes have interacted with eukaryotic cells for as long as they have been
co-existing. While many of these interactions are beneficial for both the microbe
as well as the eukaryotic cell, several microbes have evolved into pathogenic
species. For some of these pathogens, host cell invasion results in irreparable
damage and thus host cell destruction, whereas others use the host to avoid
immune detection and elimination. One of the latter pathogens is Mycobacterium
tuberculosis, arguably one of the most notorious pathogens on earth. In mammalian
macrophages, M. tuberculosis manages to survive within infected macrophages by
avoiding intracellular degradation in lysosomes using a number of different
strategies. One of these is based on the recruitment and phagosomal retention of
the host protein coronin 1, that is a member of the coronin protein family and a
mammalian homolog of coronin A, a protein identified in Dictyostelium. Besides
mediating mycobacterial survival in macrophages, coronin 1 is also an important
regulator of naïve T cell homeostasis. How, exactly, coronin 1 mediates its
activity in immune cells remains unclear. While in lower eukaryotes coronins are
involved in cytoskeletal regulation, the functions of the seven coronin members
in mammals are less clear. Dictyostelium coronins may have maintained multiple
functions, whereas the mammalian coronins may have evolved from regulators of the
cytoskeleton to modulators of signal transduction. In this minireview, we will
discuss the different studies that have contributed to understand the molecular
and cellular functions of coronin proteins in mammals and Dictyostelium.
free
free
free
