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10.3892/ijo.2018.4327 http://scihub22266oqcxt.onion/10.3892/ijo.2018.4327 C5873898!5873898 !29568938     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29568938 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2018 ; 52 (5 ): 1455-1464 Nephropedia Template TP {{tp|p=29568938 |t=2018. FSCN?1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition |pdf=|usr=}}{{29568938 }} gab.com Text FSCN 1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29568938 #FOAvip Resistance to chemotherapy drugs remains a significant problem for the treatment of many types of cancer. Fascin?1 (FSCN?1) is an actin-bundling protein involved in the invasion and metastasis of a variety of tumors. However, its involvement in drug resistance in hepatocellular carcinoma (HCC) remains unclear. The present study aimed to investigate the function of FSCN?1 in HCC resistance to doxorubicin (DOX). FSCN?1 expression was increased in DOX-resistant HCC cell lines (SNU449 and SNU387) compared with DOX-sensitive cell lines (Huh7 and Hep3B). The resistance of HCC cells to DOX was decreased following FSCN?1 knockdown with small interfering RNA. FSCN?1 knockdown also significantly altered the expression of key markers of epithelial-mesenchymal transition (EMT). Notably, vimentin expression was reduced and epithelial?cadherin expression was increased. Furthermore, when EMT was suppressed through knockdown of Twist, an essential pathway of DOX-induced EMT, the viability of HCC cells following treatment with DOX was not affected by FSCN?1 expression. Furthermore, FSCN?1 knockdown eliminated hypoxia-induced doxorubicin resistance and EMT. The results of the present study indicated that FSCN?1 expression increased DOX resistance in HCC cells via the promotion of EMT, and this phenomenon was maintained in a hypoxic environment. FSCN?1 potentially represents a novel target to overcome resistance to DOX in HCC. Twit Text FOAVip FSCN 1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29568938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568938 #FOAvip English Wikipedia <ref>{{Cite pmid|29568938 }}</ref> FSCN?1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition #MMPMID29568938 Zhang Y ; Lu Y ; Zhang C ; Huang D ; Wu W ; Zhang Y ; Shen J ; Cai Y ; Chen W ; Yao W Int J Oncol 2018[May]; 52 (5 ): 1455-1464 PMID29568938 show ga Resistance to chemotherapy drugs remains a significant problem for the treatment of many types of cancer. Fascin?1 (FSCN?1) is an actin-bundling protein involved in the invasion and metastasis of a variety of tumors. However, its involvement in drug resistance in hepatocellular carcinoma (HCC) remains unclear. The present study aimed to investigate the function of FSCN?1 in HCC resistance to doxorubicin (DOX). FSCN?1 expression was increased in DOX-resistant HCC cell lines (SNU449 and SNU387) compared with DOX-sensitive cell lines (Huh7 and Hep3B). The resistance of HCC cells to DOX was decreased following FSCN?1 knockdown with small interfering RNA. FSCN?1 knockdown also significantly altered the expression of key markers of epithelial-mesenchymal transition (EMT). Notably, vimentin expression was reduced and epithelial?cadherin expression was increased. Furthermore, when EMT was suppressed through knockdown of Twist, an essential pathway of DOX-induced EMT, the viability of HCC cells following treatment with DOX was not affected by FSCN?1 expression. Furthermore, FSCN?1 knockdown eliminated hypoxia-induced doxorubicin resistance and EMT. The results of the present study indicated that FSCN?1 expression increased DOX resistance in HCC cells via the promotion of EMT, and this phenomenon was maintained in a hypoxic environment. FSCN?1 potentially represents a novel target to overcome resistance to DOX in HCC. äFSCN?1 increases doxorubicin resistance in hepatocellular carcinoma th(epmc).pdf DeepDyve Pubget Overpricing