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10.1172/JCI95127 http://scihub22266oqcxt.onion/10.1172/JCI95127 C5873886!5873886 !29553486     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29553486 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2018 ; 128 (4 ): 1627-1640 Nephropedia Template TP {{tp|p=29553486 |t=2018. The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques |pdf=|usr=}}{{29553486 }} gab.com Text The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=29553486 #FOAvip Apoptosis has been proposed as a key mechanism responsible for CD4+ T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SIV-infected rhesus macaques (RMs). When administered during the acute phase of infection, Q-VD-OPH was associated with (a) reduced levels of T cell death, (b) preservation of CD4+/CD8+ T cell ratio in lymphoid organs and in the gut, (c) maintenance of memory CD4+ T cells, and (d) increased specific CD4+ T cell response associated with the expression of cytotoxic molecules. Although therapy was limited to the acute phase of infection, Q-VD-OPH-treated RMs showed lower levels of both viral load and cell-associated SIV DNA as compared with control SIV-infected RMs throughout the chronic phase of infection, and prevented the development of AIDS. Overall, our data demonstrate that Q-VD-OPH injection in SIV-infected RMs may represent an adjunctive therapeutic agent to control HIV infection and delaying disease progression to AIDS. Twit Text FOAVip The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=29553486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29553486 #FOAvip English Wikipedia <ref>{{Cite pmid|29553486 }}</ref> The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques #MMPMID29553486 Laforge M ; Silvestre R ; Rodrigues V ; Garibal J ; Campillo-Gimenez L ; Mouhamad S ; Monceaux V ; Cumont MC ; Rabezanahary H ; Pruvost A ; Cordeiro-da-Silva A ; Hurtrel B ; Silvestri G ; Senik A ; Estaquier J J Clin Invest 2018[Apr]; 128 (4 ): 1627-1640 PMID29553486 show ga Apoptosis has been proposed as a key mechanism responsible for CD4+ T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SIV-infected rhesus macaques (RMs). When administered during the acute phase of infection, Q-VD-OPH was associated with (a) reduced levels of T cell death, (b) preservation of CD4+/CD8+ T cell ratio in lymphoid organs and in the gut, (c) maintenance of memory CD4+ T cells, and (d) increased specific CD4+ T cell response associated with the expression of cytotoxic molecules. Although therapy was limited to the acute phase of infection, Q-VD-OPH-treated RMs showed lower levels of both viral load and cell-associated SIV DNA as compared with control SIV-infected RMs throughout the chronic phase of infection, and prevented the development of AIDS. Overall, our data demonstrate that Q-VD-OPH injection in SIV-infected RMs may represent an adjunctive therapeutic agent to control HIV infection and delaying disease progression to AIDS. |Acquired Immunodeficiency Syndrome/*drug therapy/enzymology/pathology [MESH] |Amino Acid Chloromethyl Ketones/*pharmacology [MESH] |Animals [MESH] |CD4-CD8 Ratio [MESH] |CD4-Positive T-Lymphocytes/enzymology/pathology [MESH] |Caspase Inhibitors/*pharmacology [MESH] |Disease Progression [MESH] |Female [MESH] |Lymphocyte Depletion [MESH] |Macaca mulatta [MESH] |Quinolines/*pharmacology [MESH] |Simian Acquired Immunodeficiency Syndrome/*drug therapy/enzymology/pathology [MESH]The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression (epmc).pdf DeepDyve Pubget Overpricing