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10.1172/JCI96139 http://scihub22266oqcxt.onion/10.1172/JCI96139 C5873875!5873875!29528335     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 128 (4): 1538-50 Nephropedia Template TP {{tp|p=29528335|t=ä. Insulin resistance causes inflammation in adipose tissue |pdf=|usr=}}{{29528335}} gab.com Text Insulin resistance causes inflammation in adipose tissue JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=29528335 #FOAvip Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activates proinflammatory macrophages. Finally, insulin resistance (high homeostatic model assessment of insulin resistance [HOMA-IR]) correlated with reduced insulin/mTORC2 signaling and elevated MCP1 production in visceral adipose tissue from obese human subjects. Our findings suggest that insulin resistance in adipose tissue leads to inflammation rather than vice versa. Twit Text FOAVip Insulin resistance causes inflammation in adipose tissue ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=29528335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29528335 #FOAvip English Wikipedia <ref>{{Cite pmid|29528335}}</ref> Insulin resistance causes inflammation in adipose tissue #MMPMID29528335 Shimobayashi M; Albert V; Woelnerhanssen B; Frei IC; Weissenberger D; Meyer-Gerspach AC; Clement N; Moes S; Colombi M; Meier JA; Swierczynska MM; Jenö P; Beglinger C; Peterli R; Hall MN J Clin Invest ä[]; 128 (4): 1538-50 PMID29528335show ga Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activates proinflammatory macrophages. Finally, insulin resistance (high homeostatic model assessment of insulin resistance [HOMA-IR]) correlated with reduced insulin/mTORC2 signaling and elevated MCP1 production in visceral adipose tissue from obese human subjects. Our findings suggest that insulin resistance in adipose tissue leads to inflammation rather than vice versa. äInsulin resistance causes inflammation in adipose tissue (epmc).pdf DeepDyve Pubget Overpricing