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10.1111/wrr.12411

http://scihub22266oqcxt.onion/10.1111/wrr.12411
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suck abstract from ncbi


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pmid26808610
      Wound+Repair+Regen 2016 ; 24 (2 ): 328-36
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  • PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis #MMPMID26808610
  • Zhang Y ; Li L ; Liu Y ; Liu ZR
  • Wound Repair Regen 2016[Mar]; 24 (2 ): 328-36 PMID26808610 show ga
  • Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. Our studies reveal a new and important molecular linker between the early inflammatory response and proliferation phase in tissue repair process.
  • |*Neovascularization, Physiologic [MESH]
  • |Animals [MESH]
  • |Cell Proliferation [MESH]
  • |Disease Models, Animal [MESH]
  • |Extracellular Matrix/pathology [MESH]
  • |Immunohistochemistry [MESH]
  • |Inflammation/enzymology/pathology [MESH]
  • |Mice [MESH]
  • |Mice, Inbred C57BL [MESH]
  • |Neutrophils/enzymology/*metabolism [MESH]
  • |Pyruvate Kinase/*metabolism [MESH]
  • |Wound Healing/*physiology [MESH]


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