Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26808610
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Wound+Repair+Regen
2016 ; 24
(2
): 328-36
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
PKM2 released by neutrophils at wound site facilitates early wound healing by
promoting angiogenesis
#MMPMID26808610
Zhang Y
; Li L
; Liu Y
; Liu ZR
Wound Repair Regen
2016[Mar]; 24
(2
): 328-36
PMID26808610
show ga
Neutrophils infiltration/activation following wound induction marks the early
inflammatory response in wound repair. However, the role of the
infiltrated/activated neutrophils in tissue regeneration/proliferation during
wound repair is not well understood. Here, we report that infiltrated/activated
neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive
mechanisms during early stages of wound repair. The released extracellular PKM2
facilitates early wound healing by promoting angiogenesis at wound site. Our
studies reveal a new and important molecular linker between the early
inflammatory response and proliferation phase in tissue repair process.