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2018 ; 11
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Optical and Electrical Characterization of Biocompatible Polymeric Lines for
Hemodialysis Applications
#MMPMID29547575
Ravagli E
; Severi S
Materials (Basel)
2018[Mar]; 11
(3
): ä PMID29547575
show ga
During hemodialysis (HD), blood is circulated through an extracorporeal tubing
system (bloodline) made of medical-grade polymeric material. Sensors of various
types that do not come into contact with blood (optical, electromagnetic, etc.)
are applied directly across the bloodline for clinical purposes and for therapy
customization. Thus, a detailed knowledge of the bloodline's physical properties
is useful for the development of next-generation HD sensors. In this work, we
performed a novel comparative analysis of the materials used by the manufacturers
of the bloodlines. We focused on signals and characterization techniques matching
those of the abovementioned sensors; consequently, this is an
application-specific study of the optical and electrical characterization of
bloodline material. Such properties are analyzed and compared for bloodlines from
seven different manufacturers by optical absorbance spectroscopy and electrical
impedance spectroscopy (EIS). Absorbance spectrum measurements are carried out in
the VIS-NIR range. Absorbance spectra are pre-processed and data from both types
of analyses are normalized with respect to sample thickness. Optical analysis
shows that all bloodlines except one have similarly shaped spectra with slight
quantitative differences. In all optical spectra, we find a decreasing trend of
specific absorption from 0.14 mm(-1) at 400 nm to 0.06 mm(-1) at 1000 nm, with an
absorption peak at 915 nm. In one case, a large absorption peak centered at ?600
nm is found. Electrical analysis shows that all bloodlines have the electrical
properties of a constant-phase element (CPE), with statistically significant
differences in parameters' values. Estimation of electrical CPE parameters for
all bloodline returns a range of 0.942-0.957 for parameter n and a range of
12.41-16.64 for parameter Q?'. In conclusion, we find that, although some
statistically significant differences are present, bloodlines from a
representative group of manufacturers share similar electrical and optical
properties. Therefore, contactless sensing devices developed for HD will work on
different bloodlines if a simple recalibration is performed.