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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nutrients
2018 ; 10
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation
End-Products in Diabetic Mice Kidney
#MMPMID29495397
Do MH
; Hur J
; Choi J
; Kim M
; Kim MJ
; Kim Y
; Ha SK
Nutrients
2018[Feb]; 10
(3
): ä PMID29495397
show ga
Eucommia ulmoides Oliv. (EU), also known as Du-Zhong, is a medicinal herb
commonly used in Asia to treat hypertension and diabetes. Despite evidence of the
protective effects of EU against diabetes, its precise effects and mechanisms of
action against advanced glycation end-products (AGEs) are unclear. In this study,
we evaluated the effects of EU on AGEs-induced renal disease and explored the
possible underlying mechanisms using streptozotocin (STZ)-induced diabetic mice.
STZ-induced diabetic mice received EU extract (200 mg/kg) orally for 6 weeks. EU
treatment did not change blood glucose and glycated hemoglobin (HbA1c) levels in
diabetic mice. However, the EU-treated group showed a significant increase in the
protein expression and activity of glyoxalase 1 (Glo1), which detoxifies the AGE
precursor, methylglyoxal (MGO). EU significantly upregulated nuclear factor
erythroid 2-related factor 2 (Nrf2) expression but downregulated that of receptor
for AGE (RAGE). Furthermore, histological and immunohistochemical analyses of
kidney tissue showed that EU reduced periodic acid-Schiff (PAS)-positive
staining, AGEs, and MGO accumulation in diabetic mice. Based on these findings,
we concluded that EU ameliorated the renal damage in diabetic mice by inhibiting
AGEs formation and RAGE expression and reducing oxidative stress, through the
Glo1 and Nrf2 pathways.
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