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2018 ; 18
(1
): 143
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Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in
China: a case report
#MMPMID29587642
Jiao J
; Wu L
; Yin J
; Quan X
; Chen W
; Hu J
BMC Infect Dis
2018[Mar]; 18
(1
): 143
PMID29587642
show ga
BACKGROUND: We describe a case of Guillain-Barre syndrome (GBS) associated with
hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS
associated with Hantavirus infection have been reported so far. CASE
PRESENTATIONS: A 62-year-old man presented intermittent fever, chill and
oliguria. According to remarkable leukocytosis, atypical lymphocytes,
thrombocytopenia and former dwelling in hemorrhagic fever-endemic area, he was
suspected as hemorrhagic fever with renal syndromeand certified with positive
Hantavirus IgG. Later, the patient had symmetrical flaccid paralysis of all
extremities. Electromyography showed peripheral nerve injury (mainly in axon).
The patient was diagnosed as having acute motor sensory axonal neuropathy
(AMSAN). After immunoglobulin infusion, patient showed progressive recovery and
was transferred 3 weeks after his first admission to a rehabilitation center.
CONCLUSIONS: Our case was the 6th reported case of GBS associated with
hemorrhagic fever with renal syndrome. Moreover, we for the first time classified
the subtype of GBS (AMSAN) based on the electrophysiology characteristics. GBS
should be suspected in patients who are already diagnosed as hemorrhagic fever
with renal syndrome when delayed symmetrical limb paralysis occurs. Until recent
now, GBS was only reported in hemorrhagic fever patients in Europe and Asia,
which termed as hemorrhagic fever with renal syndrome.