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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Fungi+(Basel) 2018 ; 4 (1): ä Nephropedia Template TP
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Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans #MMPMID29463005
Denham ST; Brown JCS
J Fungi (Basel) 2018[Mar]; 4 (1): ä PMID29463005show ga
Cryptococcus neoformans is a common environmental saprophyte and human fungal pathogen that primarily causes disease in immunocompromised individuals. Similar to many environmentally acquired human fungal pathogens, C. neoformans initiates infection in the lungs. However, the main driver of mortality is invasive cryptococcosis leading to fungal meningitis. After C. neoformans gains a foothold in the lungs, a critical early step in invasion is transversal of the respiratory epithelium. In this review, we summarize current knowledge relating to pulmonary escape. We focus on fungal factors that allow C. neoformans to disseminate from the lungs via intracellular and extracellular routes.