Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-018-03619-9 http://scihub22266oqcxt.onion/10.1038/s41467-018-03619-9 C5872006!5872006!29593265     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29593265|t=2018. Lymphotoxin ? fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells |pdf=|usr=}}{{29593265}} gab.com Text Lymphotoxin fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29593265 #FOAvip Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of autoreactive thymocytes. Although dendritic cells (DC) reinforce this process by transporting innocuous peripheral self-antigens, the mechanisms that control their thymic entry remain unclear. Here we show that mTEC-CD4+ thymocyte crosstalk regulates the thymus homing of SHPS-1+ conventional DCs (cDC), plasmacytoid DCs (pDC) and macrophages. This homing process is controlled by lymphotoxin ? (LT?), which negatively regulates CCL2, CCL8 and CCL12 chemokines in mTECs. Consequently, Lt?-deficient mice have increased expression of these chemokines that correlates with augmented classical NF-?B subunits and increased thymic recruitment of cDCs, pDCs and macrophages. This enhanced migration depends mainly on the chemokine receptor CCR2, and increases thymic clonal deletion. Altogether, this study identifies a fine-tuning mechanism of T cell repertoire selection and paves the way for therapeutic interventions to treat autoimmune disorders. Twit Text FOAVip Lymphotoxin fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29593265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29593265 #FOAvip English Wikipedia <ref>{{Cite pmid|29593265}}</ref> Lymphotoxin ? fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells #MMPMID29593265 Lopes N; Charaix J; Cédile O; Sergé A; Irla M Nat Commun 2018[]; 9 (ä): ä PMID29593265show ga Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of autoreactive thymocytes. Although dendritic cells (DC) reinforce this process by transporting innocuous peripheral self-antigens, the mechanisms that control their thymic entry remain unclear. Here we show that mTEC-CD4+ thymocyte crosstalk regulates the thymus homing of SHPS-1+ conventional DCs (cDC), plasmacytoid DCs (pDC) and macrophages. This homing process is controlled by lymphotoxin ? (LT?), which negatively regulates CCL2, CCL8 and CCL12 chemokines in mTECs. Consequently, Lt?-deficient mice have increased expression of these chemokines that correlates with augmented classical NF-?B subunits and increased thymic recruitment of cDCs, pDCs and macrophages. This enhanced migration depends mainly on the chemokine receptor CCR2, and increases thymic clonal deletion. Altogether, this study identifies a fine-tuning mechanism of T cell repertoire selection and paves the way for therapeutic interventions to treat autoimmune disorders. äLymphotoxin ? fine-tunes T cell clonal deletion by regulating thymic e(epmc).pdf DeepDyve Pubget Overpricing