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10.1038/s41467-018-03641-x http://scihub22266oqcxt.onion/10.1038/s41467-018-03641-x C5871873!5871873!29593297     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29593297|t=2018. Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation |pdf=|usr=}}{{29593297}} gab.com Text Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29593297 #FOAvip Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive breast carcinomas. Moreover, we identify another recurrent feature of cancer cells: centriole size deregulation. Further experiments demonstrate that severe centriole over-elongation can promote amplification through both centriole fragmentation and ectopic procentriole formation. Furthermore, we show that overly long centrioles form over-active centrosomes that nucleate more microtubules, a known cause of invasiveness, and perturb chromosome segregation. Our screen establishes centriole amplification and size deregulation as recurrent features of cancer cells and identifies novel causes and consequences of those abnormalities. Twit Text FOAVip Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29593297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29593297 #FOAvip English Wikipedia <ref>{{Cite pmid|29593297}}</ref> Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation #MMPMID29593297 Marteil G; Guerrero A; Vieira AF; de Almeida BP; Machado P; Mendonça S; Mesquita M; Villarreal B; Fonseca I; Francia ME; Dores K; Martins NP; Jana SC; Tranfield EM; Barbosa-Morais NL; Paredes J; Pellman D; Godinho SA; Bettencourt-Dias M Nat Commun 2018[]; 9 (ä): ä PMID29593297show ga Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive breast carcinomas. Moreover, we identify another recurrent feature of cancer cells: centriole size deregulation. Further experiments demonstrate that severe centriole over-elongation can promote amplification through both centriole fragmentation and ectopic procentriole formation. Furthermore, we show that overly long centrioles form over-active centrosomes that nucleate more microtubules, a known cause of invasiveness, and perturb chromosome segregation. Our screen establishes centriole amplification and size deregulation as recurrent features of cancer cells and identifies novel causes and consequences of those abnormalities. äOver-elongation of centrioles in cancer promotes centriole amplificati(epmc).pdf DeepDyve Pubget Overpricing