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10.1038/s41598-018-23565-2 http://scihub22266oqcxt.onion/10.1038/s41598-018-23565-2 C5871862!5871862 !29593222     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29593222 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 5334 Nephropedia Template TP {{tp|p=29593222 |t=2018. CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy |pdf=|usr=}}{{29593222 }} gab.com Text CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29593222 #FOAvip Experimental aristolochic acid nephropathy is characterized by transient acute proximal tubule necrosis and inflammatory cell infiltrates followed by interstitial fibrosis and tubular atrophy. The respective role of T-cell subpopulations has never been studied in the acute phase of the mouse model, and was heretofore exclusively investigated by the use of several depletion protocols. As compared to mice injected with aristolochic acids alone, more severe acute kidney injury was observed after CD4(+) or CD8(+) T-cells depletion. TNF-alpha and MCP-1 mRNA renal expressions were also increased. In contrast, regulatory T-cells depletion did not modify the severity of the aristolochic acids induced acute kidney injury, suggesting an independent mechanism. Aristolochic acids nephropathy was also associated with an increased proportion of myeloid CD11b(high)F4/80(mid) and a decreased proportion of their counterpart CD11b(low)F4/80(high) population. After CD4(+) T-cell depletion the increase in the CD11b(high)F4/80(mid) population was even higher whereas the decrease in the CD11b(low)F4/80(high) population was more marked after CD8+ T cells depletion. Our results suggest that CD4(+) and CD8(+) T-cells provide protection against AA-induced acute tubular necrosis. Interestingly, T-cell depletion was associated with an imbalance of the CD11b(high)F4/80(mid) and CD11b(low)F4/80(high) populations. Twit Text FOAVip CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29593222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29593222 #FOAvip English Wikipedia <ref>{{Cite pmid|29593222 }}</ref> CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy #MMPMID29593222 Baudoux T ; Husson C ; De Prez E ; Jadot I ; Antoine MH ; Nortier JL ; Hougardy JM Sci Rep 2018[Mar]; 8 (1 ): 5334 PMID29593222 show ga Experimental aristolochic acid nephropathy is characterized by transient acute proximal tubule necrosis and inflammatory cell infiltrates followed by interstitial fibrosis and tubular atrophy. The respective role of T-cell subpopulations has never been studied in the acute phase of the mouse model, and was heretofore exclusively investigated by the use of several depletion protocols. As compared to mice injected with aristolochic acids alone, more severe acute kidney injury was observed after CD4(+) or CD8(+) T-cells depletion. TNF-alpha and MCP-1 mRNA renal expressions were also increased. In contrast, regulatory T-cells depletion did not modify the severity of the aristolochic acids induced acute kidney injury, suggesting an independent mechanism. Aristolochic acids nephropathy was also associated with an increased proportion of myeloid CD11b(high)F4/80(mid) and a decreased proportion of their counterpart CD11b(low)F4/80(high) population. After CD4(+) T-cell depletion the increase in the CD11b(high)F4/80(mid) population was even higher whereas the decrease in the CD11b(low)F4/80(high) population was more marked after CD8+ T cells depletion. Our results suggest that CD4(+) and CD8(+) T-cells provide protection against AA-induced acute tubular necrosis. Interestingly, T-cell depletion was associated with an imbalance of the CD11b(high)F4/80(mid) and CD11b(low)F4/80(high) populations. |*Immunomodulation [MESH] |Acute Kidney Injury/*etiology/*metabolism/pathology [MESH] |Animals [MESH] |Aristolochic Acids/*adverse effects [MESH] |Biomarkers [MESH] |CD4-Positive T-Lymphocytes/*immunology/*metabolism [MESH] |CD8-Positive T-Lymphocytes/*immunology/*metabolism [MESH] |Disease Models, Animal [MESH] |Immunohistochemistry [MESH] |Immunophenotyping [MESH] |Kidney/immunology/metabolism/pathology [MESH] |Lymphocyte Depletion [MESH] |Male [MESH] |Mice [MESH] |Spleen/immunology/metabolism/pathology [MESH]CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimen(epmc).pdf DeepDyve Pubget Overpricing