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10.1038/ncb3400 http://scihub22266oqcxt.onion/10.1038/ncb3400 C5870829!5870829!27548914     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2016 ; 18 (9): 967-78 Nephropedia Template TP {{tp|p=27548914|t=2016. A single dividing cell population with imbalanced fate drives oesophageal tumour growth |pdf=|usr=}}{{27548914}} gab.com Text A single dividing cell population with imbalanced fate drives oesophageal tumour growth JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27548914 #FOAvip Understanding the cellular mechanisms of tumour growth is key for designing rational anti-cancer treatment. Here we used genetic lineage tracing to quantify cell behaviour during neoplastic transformation in a model of oesophageal carcinogenesis. We found that cell behaviour was convergent across premalignant tumours, which contained a single proliferating cell population. The rate of cell division was not significantly different in the lesions and the surrounding epithelium. However, dividing tumour cells had a uniform, small bias in cell fate so that, on average, slightly more dividing than non-dividing daughter cells were generated at each round of cell division. In invasive cancers induced by KrasG12D expression, dividing cell fate became more strongly biased towards producing dividing over non-dividing cells in a subset of clones. These observations argue that agents that restore the balance of cell fate may prove effective in checking tumour growth, whereas those targeting proliferation may show little selectivity. Twit Text FOAVip A single dividing cell population with imbalanced fate drives oesophageal tumour growth ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27548914 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27548914 #FOAvip English Wikipedia <ref>{{Cite pmid|27548914}}</ref> A single dividing cell population with imbalanced fate drives oesophageal tumour growth #MMPMID27548914 Frede J; Greulich P; Nagy T; Simons BD; Jones PH Nat Cell Biol 2016[Sep]; 18 (9): 967-78 PMID27548914show ga Understanding the cellular mechanisms of tumour growth is key for designing rational anti-cancer treatment. Here we used genetic lineage tracing to quantify cell behaviour during neoplastic transformation in a model of oesophageal carcinogenesis. We found that cell behaviour was convergent across premalignant tumours, which contained a single proliferating cell population. The rate of cell division was not significantly different in the lesions and the surrounding epithelium. However, dividing tumour cells had a uniform, small bias in cell fate so that, on average, slightly more dividing than non-dividing daughter cells were generated at each round of cell division. In invasive cancers induced by KrasG12D expression, dividing cell fate became more strongly biased towards producing dividing over non-dividing cells in a subset of clones. These observations argue that agents that restore the balance of cell fate may prove effective in checking tumour growth, whereas those targeting proliferation may show little selectivity. äA single dividing cell population with imbalanced fate drives oesophag(epmc).pdf DeepDyve Pubget Overpricing