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10.1186/s40246-018-0148-4 http://scihub22266oqcxt.onion/10.1186/s40246-018-0148-4 C5870816!5870816!29587854     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Genomics 2018 ; 12 (ä): ä Nephropedia Template TP {{tp|p=29587854|t=2018. Large-scale discovery of previously undetected microRNAs specific to human liver |pdf=|usr=}}{{29587854}} gab.com Text Large-scale discovery of previously undetected microRNAs specific to human liver JO: Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=29587854 #FOAvip MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules that are conserved across several tissues, largely excluding lineage and tissue-specific miRNAs. By analyzing small non-coding RNA sequencing data for abundance and secondary RNA structure, we discovered 103 miRNA candidates previously undescribed in liver tissue. While expression of some of these unannotated sequences is restricted to non-malignant tissue, downregulation of most of the sequences was detected in liver tumors, indicating their importance in the maintenance of liver homeostasis. Furthermore, target prediction revealed the involvement of the unannotated miRNA candidates in fatty-acid metabolism and tissue regeneration, which are key pathways in liver biology. Here, we provide a comprehensive analysis of the undiscovered liver miRNA transcriptome, providing new resources for a deeper exploration of organ-specific biology and disease.Electronic supplementary material: The online version of this article (10.1186/s40246-018-0148-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Large-scale discovery of previously undetected microRNAs specific to human liver ????Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=29587854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29587854 #FOAvip English Wikipedia <ref>{{Cite pmid|29587854}}</ref> Large-scale discovery of previously undetected microRNAs specific to human liver #MMPMID29587854 Minatel BC; Martinez VD; Ng KW; Sage AP; Tokar T; Marshall EA; Anderson C; Enfield KSS; Stewart GL; Reis PP; Jurisica I; Lam WL Hum Genomics 2018[]; 12 (ä): ä PMID29587854show ga MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules that are conserved across several tissues, largely excluding lineage and tissue-specific miRNAs. By analyzing small non-coding RNA sequencing data for abundance and secondary RNA structure, we discovered 103 miRNA candidates previously undescribed in liver tissue. While expression of some of these unannotated sequences is restricted to non-malignant tissue, downregulation of most of the sequences was detected in liver tumors, indicating their importance in the maintenance of liver homeostasis. Furthermore, target prediction revealed the involvement of the unannotated miRNA candidates in fatty-acid metabolism and tissue regeneration, which are key pathways in liver biology. Here, we provide a comprehensive analysis of the undiscovered liver miRNA transcriptome, providing new resources for a deeper exploration of organ-specific biology and disease.Electronic supplementary material: The online version of this article (10.1186/s40246-018-0148-4) contains supplementary material, which is available to authorized users. äLarge-scale discovery of previously undetected microRNAs specific to h(epmc).pdf DeepDyve Pubget Overpricing