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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Bioinformatics 2017 ; 33 (14): i261-6 Nephropedia Template TP
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miniMDS: 3D structural inference from high-resolution Hi-C data #MMPMID28882003
Rieber L; Mahony S
Bioinformatics 2017[Jul]; 33 (14): i261-6 PMID28882003show ga
Motivation: Recent experiments have provided Hi-C data at resolution as high as 1 kbp. However, 3D structural inference from high-resolution Hi-C datasets is often computationally unfeasible using existing methods. Results: We have developed miniMDS, an approximation of multidimensional scaling (MDS) that partitions a Hi-C dataset, performs high-resolution MDS separately on each partition, and then reassembles the partitions using low-resolution MDS. miniMDS is faster, more accurate, and uses less memory than existing methods for inferring the human genome at high resolution (10 kbp). Availability and implementation: A Python implementation of miniMDS is available on GitHub: https://github.com/seqcode/miniMDS. Supplementary information: Supplementary data are available at Bioinformatics online.