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10.2147/OTT.S161835 http://scihub22266oqcxt.onion/10.2147/OTT.S161835 C5870636!5870636!29615842     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Onco+Targets+Ther 2018 ; 11 (ä): 1671-81 Nephropedia Template TP {{tp|p=29615842|t=2018. MiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1 |pdf=|usr=}}{{29615842}} gab.com Text MiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1 JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29615842 #FOAvip Background: MiR-216b has been reported to be involved in the development of some cancers, however, the role of miR-216b in colorectal cancer (CRC) remains unclear. Purpose: This study aimed to investigate the mechanism underlying miR-216b-induced CRC development. Methods: We detected the expression of miR-216b in 80 cases of CRC tissues and cell lines, and further analyzed the association between miR-216b and clinical pathological indicators as well as prognosis. In vitro, the miR-216b overexpression cell model was established for further functional assay. Results: We demonstrated that miR-216b in CRC tissues and cell lines was markedly decreased compared with corresponding adjacent normal tissues and colonic mucosal epithelial cell line, and was obviously associated with the TNM stage, lymph node metastases, and poor overall survival as well as recurrence-free survival. Furthermore, we found that miR-216b inhibited cell proliferation, cell cycle, migration, and invasion by targeting 3?-UTR of SRPK1. Besides, SRPK1 over-expression reversed miR-216b-inhibited cell proliferation, migration and invasion, while SRPK1 inhibition aggravated these effects. Conclusions: We identified that miR-216b suppresses colorectal cancer proliferation, migration and invasion by targeting SRPK1, which shed light on how miR-216b functions in CRC pathogenesis. Twit Text FOAVip MiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1 ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29615842 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615842 #FOAvip English Wikipedia <ref>{{Cite pmid|29615842}}</ref> MiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1 #MMPMID29615842 Yao Y; Li Q; Wang H Onco Targets Ther 2018[]; 11 (ä): 1671-81 PMID29615842show ga Background: MiR-216b has been reported to be involved in the development of some cancers, however, the role of miR-216b in colorectal cancer (CRC) remains unclear. Purpose: This study aimed to investigate the mechanism underlying miR-216b-induced CRC development. Methods: We detected the expression of miR-216b in 80 cases of CRC tissues and cell lines, and further analyzed the association between miR-216b and clinical pathological indicators as well as prognosis. In vitro, the miR-216b overexpression cell model was established for further functional assay. Results: We demonstrated that miR-216b in CRC tissues and cell lines was markedly decreased compared with corresponding adjacent normal tissues and colonic mucosal epithelial cell line, and was obviously associated with the TNM stage, lymph node metastases, and poor overall survival as well as recurrence-free survival. Furthermore, we found that miR-216b inhibited cell proliferation, cell cycle, migration, and invasion by targeting 3?-UTR of SRPK1. Besides, SRPK1 over-expression reversed miR-216b-inhibited cell proliferation, migration and invasion, while SRPK1 inhibition aggravated these effects. Conclusions: We identified that miR-216b suppresses colorectal cancer proliferation, migration and invasion by targeting SRPK1, which shed light on how miR-216b functions in CRC pathogenesis. äMiR-216b suppresses colorectal cancer proliferation, migration, and in(epmc).pdf DeepDyve Pubget Overpricing