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10.1038/s41419-017-0048-x http://scihub22266oqcxt.onion/10.1038/s41419-017-0048-x C5870598!5870598 !29238068     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29238068 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (12 ): 3213 Nephropedia Template TP {{tp|p=29238068 |t=2017. MicroRNA-105 is involved in TNF-?-related tumor microenvironment enhanced colorectal cancer progression |pdf=|usr=}}{{29238068 }} gab.com Text MicroRNA-105 is involved in TNF- -related tumor microenvironment enhanced colorectal cancer progression JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29238068 #FOAvip TNF-? is a central proinflammatory cytokine contributing to malignant tumor progression in tumor microenvironment. In this study, we found the upregulation of miR-105 in colorectal cancer was associated with aggressive phenotype, and the enhanced expression of miR-105 was required for TNF-?-induced epithelial-mesenchymal transition (EMT). The expression of miR-105 was remarkably stimulated by TNF-? in a time-dependent manner using real-time qPCR analysis. Inhibition of miR-105 remarkably weakened the aggressive effects of TNF-? through preventing the activation of NF-?B signaling and the initiation of EMT. Furthermore, miR-105 was demonstrated directly targeted on the 3'-UTRs of RAP2C, a Rap2 subfamily of small GTP-binding protein. Consistently, suppression of RAP2C stimulated the role of miR-105, which dramatically promoted the invasion and metastasis of CRC cells. Thalidomide, a TNF-? and NF-?B inhibitor, significantly weakened the metastasis and homing capacity of miR-105-overexpressed CRC cells in nude mice. Our investigation initiatively illustrated the modulatory role of miR-105 in TNF-?-induced EMT and further CRC metastasis. We also offer a better understanding of TNF?-induced metastasis and suggest an effective therapeutic strategy against CRC metastasis. Twit Text FOAVip MicroRNA-105 is involved in TNF- -related tumor microenvironment enhanced colorectal cancer progression ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29238068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29238068 #FOAvip English Wikipedia <ref>{{Cite pmid|29238068 }}</ref> MicroRNA-105 is involved in TNF-?-related tumor microenvironment enhanced colorectal cancer progression #MMPMID29238068 Shen Z ; Zhou R ; Liu C ; Wang Y ; Zhan W ; Shao Z ; Liu J ; Zhang F ; Xu L ; Zhou X ; Qi L ; Bo F ; Ding Y ; Zhao L Cell Death Dis 2017[Dec]; 8 (12 ): 3213 PMID29238068 show ga TNF-? is a central proinflammatory cytokine contributing to malignant tumor progression in tumor microenvironment. In this study, we found the upregulation of miR-105 in colorectal cancer was associated with aggressive phenotype, and the enhanced expression of miR-105 was required for TNF-?-induced epithelial-mesenchymal transition (EMT). The expression of miR-105 was remarkably stimulated by TNF-? in a time-dependent manner using real-time qPCR analysis. Inhibition of miR-105 remarkably weakened the aggressive effects of TNF-? through preventing the activation of NF-?B signaling and the initiation of EMT. Furthermore, miR-105 was demonstrated directly targeted on the 3'-UTRs of RAP2C, a Rap2 subfamily of small GTP-binding protein. Consistently, suppression of RAP2C stimulated the role of miR-105, which dramatically promoted the invasion and metastasis of CRC cells. Thalidomide, a TNF-? and NF-?B inhibitor, significantly weakened the metastasis and homing capacity of miR-105-overexpressed CRC cells in nude mice. Our investigation initiatively illustrated the modulatory role of miR-105 in TNF-?-induced EMT and further CRC metastasis. We also offer a better understanding of TNF?-induced metastasis and suggest an effective therapeutic strategy against CRC metastasis. |*Gene Expression Regulation, Neoplastic [MESH] |3' Untranslated Regions [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Cell Line, Tumor [MESH] |Colorectal Neoplasms/drug therapy/*genetics/metabolism/pathology [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Humans [MESH] |Lymphatic Metastasis [MESH] |Mice [MESH] |Mice, Nude [MESH] |MicroRNAs/*genetics/metabolism [MESH] |NF-kappa B/antagonists & inhibitors/*genetics/metabolism [MESH] |Signal Transduction [MESH] |Thalidomide/pharmacology [MESH] |Tumor Microenvironment/drug effects/*genetics [MESH] |Tumor Necrosis Factor-alpha/antagonists & inhibitors/*genetics/metabolism [MESH] |Xenograft Model Antitumor Assays [MESH]MicroRNA-105 is involved in TNF-?-related tumor microenvironment enhan(epmc).pdf DeepDyve Pubget Overpricing