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10.1038/s41419-017-0011-x http://scihub22266oqcxt.onion/10.1038/s41419-017-0011-x C5870595!5870595 !29238039     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29238039 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (12 ): 3207 Nephropedia Template TP {{tp|p=29238039 |t=2017. Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway |pdf=|usr=}}{{29238039 }} gab.com Text Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29238039 #FOAvip The Helicobacter pylori vacuolating cytotoxin (VacA) can promote progressive vacuolation and gastric injury and may be associated with human gastric cancer. Increasing evidence indicates that autophagy is involved in the cell death induced by VacA, but the specific mechanisms need to be further elucidated. We show here that VacA could induce autophagy and increase cell death in human gastric cancer cell lines. Further investigations revealed that inhibition of autophagy could decrease the VacA-induced cell death in AGS cells. Furthermore, numerous dilated endoplasmic reticula (ER) were observed, and the phosphorylation of a subunit of eukaryotic translation initiation factor 2 subunit 1 also increased in the VacA-treated AGS cells, while repression of ER stress could reduce autophagy and cell death through knockdown of activating transcription factor 4 and DNA-damage-inducible transcript 3. In addition, the expression of pseudokinase tribbles homolog 3 (TRIB3) upon ER stress was triggered by VacA, and knockdown of TRIB3 could also decrease VacA-induced cell death. Finally, inhibition of autophagy could decrease VacA (s1m1) -induced cell death and apoptosis, and apoptosis inhibitor Z-VAD had no significant effect on autophagy induced by VacA (s1m1) . Thus, these results suggested that VacA causes autophagic cell death via ER stress in gastric epithelial cells. Twit Text FOAVip Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29238039 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29238039 #FOAvip English Wikipedia <ref>{{Cite pmid|29238039 }}</ref> Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway #MMPMID29238039 Zhu P ; Xue J ; Zhang ZJ ; Jia YP ; Tong YN ; Han D ; Li Q ; Xiang Y ; Mao XH ; Tang B Cell Death Dis 2017[Dec]; 8 (12 ): 3207 PMID29238039 show ga The Helicobacter pylori vacuolating cytotoxin (VacA) can promote progressive vacuolation and gastric injury and may be associated with human gastric cancer. Increasing evidence indicates that autophagy is involved in the cell death induced by VacA, but the specific mechanisms need to be further elucidated. We show here that VacA could induce autophagy and increase cell death in human gastric cancer cell lines. Further investigations revealed that inhibition of autophagy could decrease the VacA-induced cell death in AGS cells. Furthermore, numerous dilated endoplasmic reticula (ER) were observed, and the phosphorylation of a subunit of eukaryotic translation initiation factor 2 subunit 1 also increased in the VacA-treated AGS cells, while repression of ER stress could reduce autophagy and cell death through knockdown of activating transcription factor 4 and DNA-damage-inducible transcript 3. In addition, the expression of pseudokinase tribbles homolog 3 (TRIB3) upon ER stress was triggered by VacA, and knockdown of TRIB3 could also decrease VacA-induced cell death. Finally, inhibition of autophagy could decrease VacA (s1m1) -induced cell death and apoptosis, and apoptosis inhibitor Z-VAD had no significant effect on autophagy induced by VacA (s1m1) . Thus, these results suggested that VacA causes autophagic cell death via ER stress in gastric epithelial cells. |*Gene Expression Regulation, Neoplastic [MESH] |Activating Transcription Factor 4/antagonists & inhibitors/*genetics/metabolism [MESH] |Adenine/analogs & derivatives/pharmacology [MESH] |Amino Acid Chloromethyl Ketones/pharmacology [MESH] |Animals [MESH] |Autophagy/*drug effects/genetics [MESH] |Bacterial Proteins/isolation & purification/*pharmacology [MESH] |Cell Cycle Proteins/antagonists & inhibitors/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Endoplasmic Reticulum Stress/*drug effects [MESH] |Endoplasmic Reticulum/drug effects/pathology/ultrastructure [MESH] |Epithelial Cells [MESH] |Eukaryotic Initiation Factor-2/genetics/metabolism [MESH] |Helicobacter pylori/*chemistry/metabolism/pathogenicity [MESH] |Humans [MESH] |Macrolides/pharmacology [MESH] |Mice [MESH] |Poly (ADP-Ribose) Polymerase-1/genetics/metabolism [MESH] |Protein Serine-Threonine Kinases/antagonists & inhibitors/genetics/metabolism [MESH] |RNA, Small Interfering/genetics/metabolism [MESH] |Repressor Proteins/antagonists & inhibitors/genetics/metabolism [MESH] |Signal Transduction [MESH] |Thapsigargin/pharmacology [MESH] |Transcription Factor CHOP/antagonists & inhibitors/*genetics/metabolism [MESH]Helicobacter pylori VacA induces autophagic cell death in gastric epit(epmc).pdf DeepDyve Pubget Overpricing