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10.1038/s41419-017-0050-3 http://scihub22266oqcxt.onion/10.1038/s41419-017-0050-3 C5870590!5870590 !29238081     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29238081 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (12 ): 3214 Nephropedia Template TP {{tp|p=29238081 |t=2017. Pyridoxine 5 -phosphate oxidase is a novel therapeutic target and regulated by the TGF-? signalling pathway in epithelial ovarian cancer |pdf=|usr=}}{{29238081 }} gab.com Text Pyridoxine 5 -phosphate oxidase is a novel therapeutic target and regulated by the TGF- signalling pathway in epithelial ovarian cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29238081 #FOAvip Pyridoxine 5'-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5'-phosphate into pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer. However, the role of PNPO and its regulatory mechanism in epithelial ovarian cancer (EOC) are unknown. In the present study, PNPO expression in human ovarian tumour tissue and its association with the clinicopathological features of patients with EOC were examined. Further, the biological function of PNPO in EOC cells and in xenograft was evaluated. We demonstrated for the first time that PNPO was overexpressed in human EOC. Knockdown of PNPO induced EOC cell apoptosis, arrested cell cycle at G2/M phase, decreased cell proliferation, migration and invasion. Xenografts of PNPO-shRNA-expressing cells into the nude mouse attenuated tumour growth. PNPO at mRNA and protein levels in EOC cells was decreased after transforming growth factor-?1 (TGF-?1) treatment. The inhibitory effect of TGF-?1 on PNPO expression was abolished in the presence of SB-431542, a TGF-? type I receptor kinase inhibitor. Moreover, we found that TGF-?1-mediated PNPO expression was at least in part through the upregulation of miR-143-3p. These data indicate a mechanism underlying PNPO regulation by the TGF-? signalling pathway. Furthermore, PLP administration reduced PNPO expression and decreased EOC cell proliferation, suggesting a feedback loop between PLP and PNPO. Thus, our findings reveal that PNPO can serve as a novel tissue biomarker of EOC and may be a potential target for therapeutic intervention. Twit Text FOAVip Pyridoxine 5 -phosphate oxidase is a novel therapeutic target and regulated by the TGF- signalling pathway in epithelial ovarian cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29238081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29238081 #FOAvip English Wikipedia <ref>{{Cite pmid|29238081 }}</ref> Pyridoxine 5 -phosphate oxidase is a novel therapeutic target and regulated by the TGF-? signalling pathway in epithelial ovarian cancer #MMPMID29238081 Zhang L ; Zhou D ; Guan W ; Ren W ; Sun W ; Shi J ; Lin Q ; Zhang J ; Qiao T ; Ye Y ; Wu Y ; Zhang Y ; Zuo X ; Connor KL ; Xu G Cell Death Dis 2017[Dec]; 8 (12 ): 3214 PMID29238081 show ga Pyridoxine 5'-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5'-phosphate into pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer. However, the role of PNPO and its regulatory mechanism in epithelial ovarian cancer (EOC) are unknown. In the present study, PNPO expression in human ovarian tumour tissue and its association with the clinicopathological features of patients with EOC were examined. Further, the biological function of PNPO in EOC cells and in xenograft was evaluated. We demonstrated for the first time that PNPO was overexpressed in human EOC. Knockdown of PNPO induced EOC cell apoptosis, arrested cell cycle at G2/M phase, decreased cell proliferation, migration and invasion. Xenografts of PNPO-shRNA-expressing cells into the nude mouse attenuated tumour growth. PNPO at mRNA and protein levels in EOC cells was decreased after transforming growth factor-?1 (TGF-?1) treatment. The inhibitory effect of TGF-?1 on PNPO expression was abolished in the presence of SB-431542, a TGF-? type I receptor kinase inhibitor. Moreover, we found that TGF-?1-mediated PNPO expression was at least in part through the upregulation of miR-143-3p. These data indicate a mechanism underlying PNPO regulation by the TGF-? signalling pathway. Furthermore, PLP administration reduced PNPO expression and decreased EOC cell proliferation, suggesting a feedback loop between PLP and PNPO. Thus, our findings reveal that PNPO can serve as a novel tissue biomarker of EOC and may be a potential target for therapeutic intervention. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Antagomirs/genetics/metabolism [MESH] |Base Sequence [MESH] |Benzamides/pharmacology [MESH] |Carcinoma, Ovarian Epithelial [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Dioxoles/pharmacology [MESH] |Female [MESH] |G2 Phase Cell Cycle Checkpoints/genetics [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |MicroRNAs/antagonists & inhibitors/*genetics/metabolism [MESH] |Neoplasms, Glandular and Epithelial/drug therapy/*genetics/metabolism/pathology [MESH] |Ovarian Neoplasms/drug therapy/*genetics/metabolism/pathology [MESH] |Protein Serine-Threonine Kinases/antagonists & inhibitors/*genetics/metabolism [MESH] |Pyridoxal Phosphate/analogs & derivatives/metabolism/pharmacology [MESH] |Pyridoxaminephosphate Oxidase/antagonists & inhibitors/*genetics/metabolism [MESH] |RNA, Small Interfering/genetics/metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/antagonists & inhibitors/*genetics/metabolism [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta1/*genetics/metabolism [MESH]Pyridoxine 5 -phosphate oxidase is a novel therapeutic target and regu(epmc).pdf DeepDyve Pubget Overpricing