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10.1186/s13045-018-0592-6 http://scihub22266oqcxt.onion/10.1186/s13045-018-0592-6 C5870075!5870075!29580257     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hematol+Oncol 2018 ; 11 (ä): ä Nephropedia Template TP {{tp|p=29580257|t=2018. Gut microbiome modulates efficacy of immune checkpoint inhibitors |pdf=|usr=}}{{29580257}} gab.com Text Gut microbiome modulates efficacy of immune checkpoint inhibitors JO: J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29580257 #FOAvip Immune checkpoint inhibitors (ICIs) therapy is a novel strategy for cancer treatments in recent years. However, it was observed that most patients treated with ICIs could not get benefit from the therapy, which led to the limitation of clinical application. Motivated by potent and durable efficacy of ICIs, oncologists endeavor to explore the mechanisms of resistance to ICIs and increase the drug sensitivity. It is known that heterogeneity of gut microbiome in populations may result in different outcomes of therapy. In xenograft model, bacteria in gut have been proved as a crucial factor regulating immunotherapy efficacy. And the similar phenomenon was obtained in patients. In this review, we summarized relevant advancements about gut microbiome and ICIs. Furthermore, we focused on modulatory function of gut microbiome in ICIs therapy and possible antitumor mechanism of specific commensals in ICIs treatment. We propose that gut microbiome is an important predictive factor, and manipulation of gut microbiome is feasible to elevate response rate in ICIs therapy. Twit Text FOAVip Gut microbiome modulates efficacy of immune checkpoint inhibitors ????J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29580257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29580257 #FOAvip English Wikipedia <ref>{{Cite pmid|29580257}}</ref> Gut microbiome modulates efficacy of immune checkpoint inhibitors #MMPMID29580257 Yi M; Yu S; Qin S; Liu Q; Xu H; Zhao W; Chu Q; Wu K J Hematol Oncol 2018[]; 11 (ä): ä PMID29580257show ga Immune checkpoint inhibitors (ICIs) therapy is a novel strategy for cancer treatments in recent years. However, it was observed that most patients treated with ICIs could not get benefit from the therapy, which led to the limitation of clinical application. Motivated by potent and durable efficacy of ICIs, oncologists endeavor to explore the mechanisms of resistance to ICIs and increase the drug sensitivity. It is known that heterogeneity of gut microbiome in populations may result in different outcomes of therapy. In xenograft model, bacteria in gut have been proved as a crucial factor regulating immunotherapy efficacy. And the similar phenomenon was obtained in patients. In this review, we summarized relevant advancements about gut microbiome and ICIs. Furthermore, we focused on modulatory function of gut microbiome in ICIs therapy and possible antitumor mechanism of specific commensals in ICIs treatment. We propose that gut microbiome is an important predictive factor, and manipulation of gut microbiome is feasible to elevate response rate in ICIs therapy. äGut microbiome modulates efficacy of immune checkpoint inhibitors (epmc).pdf DeepDyve Pubget Overpricing