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10.1042/EBC20170041 http://scihub22266oqcxt.onion/10.1042/EBC20170041 C5869862!5869862 !29118097     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29118097 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Essays+Biochem 2017 ; 61 (5 ): 505-516 Nephropedia Template TP {{tp|p=29118097 |t=2017. Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders |pdf=|usr=}}{{29118097 }} gab.com Text Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders JO: Essays Biochem http://www.kidney.de/pget.php?&tw=1&pmid=29118097 #FOAvip Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought 'undruggable' targets at sub-stoichiometric concentrations in ways not possible using conventional inhibitors. Mounting evidence suggests these chemical agents, in concert with their target proteins, can be modelled as three-body binding equilibria that can exhibit significant cooperativity as a result of specific ligand-induced molecular recognition. Despite this, many existing drug design and optimization regimens still fixate on binary target engagement, in part due to limited structural data on ternary complexes. Recent crystal structures of protein complexes mediated by degrader molecules, including the first PROTAC ternary complex, underscore the importance of protein-protein interactions and intramolecular contacts to the mode of action of this class of compounds. These discoveries have opened the door to a new paradigm for structure-guided drug design: borrowing surface area and molecular recognition from nature to elicit cellular signalling. Twit Text FOAVip Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders ????Essays Biochem http://www.kidney.de/pget.php?&tw=1&pmid=29118097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29118097 #FOAvip English Wikipedia <ref>{{Cite pmid|29118097 }}</ref> Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders #MMPMID29118097 Hughes SJ ; Ciulli A Essays Biochem 2017[Nov]; 61 (5 ): 505-516 PMID29118097 show ga Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought 'undruggable' targets at sub-stoichiometric concentrations in ways not possible using conventional inhibitors. Mounting evidence suggests these chemical agents, in concert with their target proteins, can be modelled as three-body binding equilibria that can exhibit significant cooperativity as a result of specific ligand-induced molecular recognition. Despite this, many existing drug design and optimization regimens still fixate on binary target engagement, in part due to limited structural data on ternary complexes. Recent crystal structures of protein complexes mediated by degrader molecules, including the first PROTAC ternary complex, underscore the importance of protein-protein interactions and intramolecular contacts to the mode of action of this class of compounds. These discoveries have opened the door to a new paradigm for structure-guided drug design: borrowing surface area and molecular recognition from nature to elicit cellular signalling. |*Drug Design [MESH] |Binding Sites [MESH] |Crystallography, X-Ray [MESH] |Drug Discovery/*methods [MESH] |Humans [MESH] |Lenalidomide [MESH] |Ligands [MESH] |Models, Molecular [MESH] |Protein Binding [MESH] |Protein Conformation [MESH] |Protein Engineering [MESH] |Proteins/antagonists & inhibitors/*chemistry/metabolism [MESH] |Proteolysis [MESH] |Small Molecule Libraries/chemical synthesis/*chemistry [MESH] |Structure-Activity Relationship [MESH]Molecular recognition of ternary complexes: a new dimension in the s(epmc).pdf DeepDyve Pubget Overpricing