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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Essays+Biochem 2017 ; 61 (6): 597-607 Nephropedia Template TP
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Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking #MMPMID29233871
Fraser J; Cabodevilla A; Simpson J; Gammoh N
Essays Biochem 2017[Dec]; 61 (6): 597-607 PMID29233871show ga
Vesicular trafficking events play key roles in the compartmentalization and proper sorting of cellular components. These events have crucial roles in sensing external signals, regulating protein activities and stimulating cell growth or death decisions. Although mutations in vesicle trafficking players are not direct drivers of cellular transformation, their activities are important in facilitating oncogenic pathways. One such pathway is the sensing of external stimuli and signalling through receptor tyrosine kinases (RTKs). The regulation of RTK activity by the endocytic pathway has been extensively studied. Compelling recent studies have begun to highlight the association between autophagy and RTK signalling. The influence of this interplay on cellular status and its relevance in disease settings will be discussed here.