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10.1042/EBC20170021 http://scihub22266oqcxt.onion/10.1042/EBC20170021 C5869855!5869855!29233870     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Essays+Biochem 2017 ; 61 (6): 585-96 Nephropedia Template TP {{tp|p=29233870|t=2017. The mammalian ULK1 complex and autophagy initiation |pdf=|usr=}}{{29233870}} gab.com Text The mammalian ULK1 complex and autophagy initiation JO: Essays Biochem http://www.kidney.de/pget.php?&tw=1&pmid=29233870 #FOAvip Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell. It also serves as a recycling pathway to maintain protein synthesis under starvation conditions. A key initial event in autophagy is formation of the autophagosome, a unique double-membrane organelle that engulfs the cytosolic cargo destined for degradation. This step is mediated by the serine/threonine protein kinase ULK1 (unc-51-like kinase 1), which functions in a complex with at least three protein partners: FIP200 (focal adhesion kinase family interacting protein of 200 kDa), ATG (autophagy-related protein) 13 (ATG13), and ATG101. In this artcile, we focus on the regulation of the ULK1 complex during autophagy initiation. The complex pattern of upstream pathways that converge on ULK1 suggests that this complex acts as a node, converting multiple signals into autophagosome formation. Here, we review our current understanding of this regulation and in turn discuss what happens downstream, once the ULK1 complex becomes activated. Twit Text FOAVip The mammalian ULK1 complex and autophagy initiation ????Essays Biochem http://www.kidney.de/pget.php?&tw=1&pmid=29233870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29233870 #FOAvip English Wikipedia <ref>{{Cite pmid|29233870}}</ref> The mammalian ULK1 complex and autophagy initiation #MMPMID29233870 Zachari M; Ganley I Essays Biochem 2017[Dec]; 61 (6): 585-96 PMID29233870show ga Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell. It also serves as a recycling pathway to maintain protein synthesis under starvation conditions. A key initial event in autophagy is formation of the autophagosome, a unique double-membrane organelle that engulfs the cytosolic cargo destined for degradation. This step is mediated by the serine/threonine protein kinase ULK1 (unc-51-like kinase 1), which functions in a complex with at least three protein partners: FIP200 (focal adhesion kinase family interacting protein of 200 kDa), ATG (autophagy-related protein) 13 (ATG13), and ATG101. In this artcile, we focus on the regulation of the ULK1 complex during autophagy initiation. The complex pattern of upstream pathways that converge on ULK1 suggests that this complex acts as a node, converting multiple signals into autophagosome formation. Here, we review our current understanding of this regulation and in turn discuss what happens downstream, once the ULK1 complex becomes activated. äThe mammalian ULK1 complex and autophagy initiation (epmc).pdf DeepDyve Pubget Overpricing